Ntrk2 activates Ras signaling through Frs2

Stable Identifier
R-NUL-9032387
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
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Ntrk2 activates Ras signaling through Frs2
In rat cells, Frs2 is involved in TrkB (Ntrk2)-mediated activation of Ras signaling. The exact mechanism has not been elucidated. It is likely that Sos1, in complex with Grb2, recruited to activated Ntrk2 receptor through phosphorylated Frs2, catalyzes guanine nucleotide exchange on Ras. Ptpn11 (Shp2) facilitates Frs2-mediated activation of Ras downstream of Ntrk2, possibly by contributing to Grb2 recruitment (Easton et al. 1999, Easton et al. 2006).
Literature References
PubMed ID Title Journal Year
16573649 The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor

Easton, JB, Royer, AR, Middlemas, DS

J. Neurochem. 2006
10196222 Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2

Middlemas, DS, Zhu, X, Moody, NM, Easton, JB

J. Biol. Chem. 1999
Participants
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF:p-5Y-Ntrk2 homodimer:p-Y-Frs2:Grb2:Sos1 [plasma membrane]

This event is regulated
Orthologous Events
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