Ntrk2 phosphorylates FRS3

Stable Identifier
R-NUL-9032423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ntrk2 phosphorylates FRS3
Activated recombinant rat Ntrk2 (TrkB) phosphorylates recombinant human FRS3 (Dixon et al. 2006).
Literature References
PubMed ID Title Journal Year
16697063 Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3

Dixon, SJ, MacDonald, JI, Kubu, CJ, Meakin, SO, Robinson, KN

Biochim. Biophys. Acta 2006
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of BDNF:p-5Y-Ntrk2 homodimer:FRS3 [plasma membrane]

Physical Entity
BDNF:p-5Y-Ntrk2 homodimer:FRS3 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
NTRK2 phosphorylates FRS3 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-13)
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