RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1

Stable Identifier
R-NUL-936401
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

RNF125 acts as an E3-ubiquitin ligase that conjugates with RIG-I, MDA5 and IPS-1 and mediate their proteosomal degradation. UbcH1, UbcH5a, UbcH5b, and UbcH5c function as an E2 enzyme and conjugate ubiquitin to RNF125 and RIG-1 via K48. Among these enzymes UbcH5c is the major E2 enzyme showing enhanced ubiquitin conjugation to RIG-I. RNF125 mediated ubiquitination of RIG-I/MDA5 and IPS1 inhibits RIG-I signaling by shunting these proteins toward proteasomal degradation.

Literature References
PubMed ID Title Journal Year
17460044 Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 Proc Natl Acad Sci U S A 2007
Participants
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of Rnf125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol]
Physical Entity
Activity
Orthologous Events