FBXW7 promotes ubiquitination of mouse p-NICD4

Stable Identifier
R-NUL-9604628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FBXW7 promotes ubiquitination of mouse p-NICD4

The human E3 ubiquitin ligase FBXW7, a component of the SCF ubiquitin ligase complex, binds to and ubiquitinates phosphorylated mouse NICD4 (Notch4 intracellular domain fragment), targeting it for proteasome-mediated degradation (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11585921 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Wu, G, Lyapina, S, Das, I, Li, J, Gurney, M, Pauley, A, Chui, I, Deshaies, RJ, Kitajewski, J

Mol Cell Biol 2001
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
Physical Entity
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)
Cross References
Target Pathogen
Authored
Orlic-Milacic, M  (2018-04-05)
Reviewed
Haw, R  (2018-05-01)
Created
Orlic-Milacic, M  (2018-04-04)
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