Nrg2-activated Erbb4 binds GABA receptors through Gabra1

Stable Identifier
R-NUL-9612654
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nrg2-activated Erbb4 binds GABA receptors through Gabra1

Rat Erbb4 activated by recombinant mouse Nrg2 binds to rat GABA receptors by directly interacting with the Gabra1 (GABA receptor alpha1) subunit. Erbb4 kinase activity is not necessary for interaction with Gabra1 (Mitchell et al. 2013).

Literature References
PubMed ID Title Journal Year
24218551 ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity

Mitchell, RM, Janssen, MJ, Karavanova, I, Vullhorst, D, Furth, K, Makusky, A, Markey, SP, Buonanno, A

Proc. Natl. Acad. Sci. U.S.A. 2013
Participants
Orthologous Events
Authored
Created
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