NAB2 binds Egr1 at the Cdk5r1 promoter

Stable Identifier
R-NUL-9616362
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NAB2 binds Egr1 at the Cdk5r1 promoter
Cotransfection of human NAB2 and constitutively active Xenopus MEK into PC12 cells inhibits the ERK-signaling dependent expression of Cdk5r1, without affecting the expression of Egr1 itself (Harada et al, 2001).
Literature References
PubMed ID Title Journal Year
11331872 ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1

Harada, T, Nishida, E, Ogawa, S, Morooka, T

Nat. Cell Biol. 2001
Participants
Input
Output
Orthologous Events
NAB2 binds EGR1 to repress CDK5R1 gene expression (Homo sapiens)
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-08-10)
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