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Ntrk3 activates Ras
Stable Identifier
R-NUL-9616949
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
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PPTX
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SBGN
In rat neurons, stimulation of Ntrk3 (TrkC) by recombinant human NTF3 (NT-3) increases the amount of GTP-bound Ras (Marsh and Palfrey 1996).
Literature References
PubMed ID
Title
Journal
Year
8752100
Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons
Marsh, HN
,
Palfrey, HC
J. Neurochem.
1996
Participants
Input
GTP [cytosol]
p21 Ras:GDP [plasma membrane]
(Rattus norvegicus)
Output
GDP [cytosol]
p21 Ras:GTP [plasma membrane]
(Rattus norvegicus)
This event is regulated
Positively by
Regulator
NTF3:p-5Y-Ntrk3 homodimer [plasma membrane]
(Homo sapiens)
Orthologous Events
NTRK3 activates RAS through SHC1 (Homo sapiens)
Authored
Orlic-Milacic, M (2018-01-02)
Reviewed
Tsoulfas, P (2018-05-09)
Created
Orlic-Milacic, M (2018-08-15)
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