EP300 binds SOH-C477-Foxo4

Stable Identifier
R-NUL-9617710
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
EP300 binds SOH-C477-Foxo4

After oxidation of a recombinant mouse Foxo4 cysteine residues by reactive oxygen species (ROS), Foxo4 forms a complex with a recombinant human protein acetyltransferase EP300 (p300). A covalent disulfide bond between Foxo4 and EP300 facilitates complex formation (Dansen et al. 2009).

Literature References
PubMed ID Title Journal Year
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, TB, Smits, LM, van Triest, MH, de Keizer, PL, van Leenen, D, Koerkamp, MG, Szypowska, A, Meppelink, A, Brenkman, AB, Yodoi, J, Holstege, FC, Burgering, BM

Nat. Chem. Biol. 2009
Participants
Orthologous Events
Authored
Reviewed
Created