TXN disrupts Foxo4 comples with EP300

Stable Identifier
R-NUL-9617742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
TXN disrupts Foxo4 comples with EP300

Recombinant human thioredoxin (TXN) reduces oxidized recombinant mouse Foxo4 and disrupts interaction between Foxo4 and recombinant human EP300. TXN-mediated disruption of Foxo4:EP300 complexes is negatively regulated by recombinant human TXNIP (TBP-2), a TXN binding protein (Dansen et al. 2009).

Literature References
PubMed ID Title Journal Year
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, TB, Smits, LM, van Triest, MH, de Keizer, PL, van Leenen, D, Koerkamp, MG, Szypowska, A, Meppelink, A, Brenkman, AB, Yodoi, J, Holstege, FC, Burgering, BM

Nat. Chem. Biol. 2009
Participants
Catalyst Activity
Catalyst Activity
Title
thioredoxin-disulfide reductase activity of TXN [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created