TXN disrupts Foxo4 comples with EP300

Stable Identifier
R-NUL-9617742
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TXN disrupts Foxo4 comples with EP300
Recombinant human thioredoxin (TXN) reduces oxidized recombinant mouse Foxo4 and disrupts interaction between Foxo4 and recombinant human EP300. TXN-mediated disruption of Foxo4:EP300 complexes is negatively regulated by recombinant human TXNIP (TBP-2), a TXN binding protein (Dansen et al. 2009).
Literature References
PubMed ID Title Journal Year
19648934 Redox-sensitive cysteines bridge p300/CBP-mediated acetylation and FoxO4 activity

Dansen, TB, Smits, LM, van Triest, MH, de Keizer, PL, van Leenen, D, Koerkamp, MG, Szypowska, A, Meppelink, A, Brenkman, AB, Yodoi, J, Holstege, FC, Burgering, BM

Nat. Chem. Biol. 2009
Participants
Input
Output
Catalyst Activity

thioredoxin-disulfide reductase (NADPH) activity of TXN [nucleoplasm]

Physical Entity
TXN [nucleoplasm] (Homo sapiens)
Activity
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
This event is regulated
Negatively by
Regulator
TXNIP [nucleoplasm] (Homo sapiens)
Orthologous Events
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Donlon, T  (2018-10-17)
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-08-30)
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