Camkk2 phosphorylates CAMK4

Stable Identifier
R-NUL-9619177
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Camkk2 phosphorylates CAMK4
In the presence of recombinant calmodulin, recombinant rat Camkk2 (CaMKK-beta) phosphorylates recombinant human CAMK4 (CaMKIV) (Anderson et al. 1998). Recombinant calmodulin is assumed to be human as CALM1 seqeuence is 100% conserved between human, rat and mouse.
Literature References
PubMed ID Title Journal Year
9822657 Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta

Huang, QH, Anderson, KA, Fremeau, RT, Edelman, AM, Goldstein, EG, Means, RL, Means, AR, Selbert, MA, Kemp, BE

J. Biol. Chem. 1998
Participants
Input
Output
Catalyst Activity

calmodulin-dependent protein kinase activity of p-Camkk2:CALM1:4xCa2+ [nucleoplasm]

Physical Entity
p-Camkk2:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Orthologous Events
CaMKK phosphorylates CAMK4 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-14)
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