Camkk2 phosphorylates AMPK

Stable Identifier
R-NUL-9619488
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Camkk2 phosphorylates AMPK
Recombinant rat Camkk2 (Camkk-beta), activated by bovine calmodulin, phosphorylates recombinant rat catalytic subunit AMPK-alpha1 (Prkaa1) of recombinant rat AMP-activated kinase (AMPK) complex, consisting of Prkaa1, Prkab1 (AMPK-beta1) and Prkag1 (AMPK-gamma1) (Woods et al. 2005).
Literature References
PubMed ID Title Journal Year
16054096 Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells

Hong, SP, Carlson, M, Johnstone, SR, Woods, A, Carling, D, Momcilovic, M, Heath, R, Dickerson, K

Cell Metab. 2005
Participants
Input
Output
Catalyst Activity

calmodulin-dependent protein kinase activity of p-Camkk2:CALM1:4xCa2+ [cytosol]

Physical Entity
p-Camkk2:CALM1:4xCa2+ [cytosol] (Bos taurus)
Activity
calmodulin-dependent protein kinase activity (GO:0004683)
Orthologous Events
CAMKK2 phosphorylates AMPK (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-17)
Cite Us!