Ghr internalization

Stable Identifier
R-OCU-1169264
Type
Reaction [omitted]
Species
Oryctolagus cuniculus
Compartment
endosome lumen, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ghr internalization
Cell surface levels of GHR are the primary determinant of GH responsiveness. This is modulated partly by endocytosis and lysosomal degradation. This downregulation is strongly inhibited by the association of JAK2 with the receptor, and by GH if JAK2 is prevented from signaling, but markedly enhanced by GH if JAK2 is kinase active. GH down-regulation also requires GHR tyrosine phosphorylation (Deng et al. 2007) and is believed to be mediated by GHR ubiquitination and proteasomal degradation.
Literature References
PubMed ID Title Journal Year
17488973 Determinants of growth hormone receptor down-regulation

Deng, L, He, K, Wang, X, Yang, N, Thangavel, C, Jiang, J, Fuchs, SY, Frank, SJ

Mol Endocrinol 2007
Participants
Input
Output
Orthologous Events
GHR internalization (Homo sapiens)
Authored
Jupe, S  (2010-10-14)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-17)
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