Reactome | HIST1H2BA [nucleoplasm]

HIST1H2BA [nucleoplasm]

Stable Identifier

R-PFA-181916

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

nucleoplasm

Synonyms

Q8IBV7

Locations in the PathwayBrowser

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Cell Cycle (Plasmodium falciparum)

- Cell Cycle, Mitotic (Plasmodium falciparum)
  - M Phase (Plasmodium falciparum)
    - Mitotic Prophase (Plasmodium falciparum)
      - Condensation of Prophase Chromosomes (Plasmodium falciparum)
        
        Condensin II complex binds H4K20me1-containing nucleosomes (Plasmodium falciparum)
        
        Condensin II:Nucleosome with H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        PHF8 demethylates histone H4K20me1 (Plasmodium falciparum)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        PLK1 binds phosphorylated condensin II complex (Plasmodium falciparum)
        
        Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        PLK1 hyperphosphorylates Condensin II complex (Plasmodium falciparum)
        
        Hyperphosphorylated Condensin II:Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        p-T210-PLK1:Phosphorylated Condensin II:Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        SETD8 monomethylates histone H4 (Plasmodium falciparum)
        
        PHF8:Nucleosome with H3K4me2/3 [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        PHF8:Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Nucleosome with H3K4me2/3:H4K20me1 [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

Chromatin organization (Plasmodium falciparum)

- Chromatin modifying enzymes (Plasmodium falciparum)
  - HDACs deacetylate histones (Plasmodium falciparum)
    - HDAC10 deacetylates histone (Plasmodium falciparum)
      - Core histone octamer [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2A:H2B [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Histone HIST1H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
    - HDAC8 deacetylates histones (Plasmodium falciparum)
      - Core histone octamer [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2A:H2B [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Histone HIST1H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

DNA Repair (Plasmodium falciparum)

- DNA Double-Strand Break Repair (Plasmodium falciparum)
  - DNA Double Strand Break Response (Plasmodium falciparum)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Plasmodium falciparum)
      - ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Plasmodium falciparum)
        
        DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        p-Y142-H2AFX-Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

DNA Replication (Plasmodium falciparum)

- DNA Replication Pre-Initiation (Plasmodium falciparum)
  - Assembly of the pre-replicative complex (Plasmodium falciparum)
    - Assembly of the ORC complex at the origin of replication (Plasmodium falciparum)
      - ORC1 binds to H4K20me2 (Plasmodium falciparum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        ORC1:H4K20Me2-nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        H4K20Me2-nucleosome [nucleoplasm] (Plasmodium falciparum)
        
        Histone H2B [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)
        
        HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:Q8IBV7

Reference Genes

BioGPS Gene:2655098

ENSEMBL:PF3D7_0714000

KEGG:pfa:PF3D7_0714000

Monarch:2655098

NCBI Gene:2655098

PlasmoDB:PF3D7_0714000

UCSC:Q8IBV7

Reference Transcript

RefSeq:XM_001349010.1

Participates

as a member of

Homologues of HIST1H2BA [nucleoplasm] (Plasmodium falciparum)

Other forms of this molecule

AcK-HIST1H2BA [nucleoplasm]

AcK-HIST1H2BB [nucleoplasm]

AcK7-HIST1H2BA [nucleoplasm]

AcK14-HIST1H2BA [nucleoplasm]

AcK17-HIST1H2BA [nucleoplasm]

AcK22-HIST1H2BA [nucleoplasm]

AcK21-HIST1H2BB [nucleoplasm]

AcK13-HIST1H2BB [nucleoplasm]

AcK16-HIST1H2BB [nucleoplasm]

AcK6-HIST1H2BB [nucleoplasm]

Ub-122-HIST1H2BA [nucleoplasm]

Ub-121-HIST1H2BK [nucleoplasm]

HIST1H2BK [nucleoplasm]

Inferred From

HIST1H2BA [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_001349046.1

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