Reactome | phospho-p-T218,Y220-MAPK7 [nucleoplasm]

phospho-p-T218,Y220-MAPK7 [nucleoplasm]

Stable Identifier

R-PFA-198738

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

nucleoplasm

Synonyms

C0H5B8

Locations in the PathwayBrowser

Expand all

Immune System (Plasmodium falciparum)

- Cytokine Signaling in Immune system (Plasmodium falciparum)
  - Signaling by Interleukins (Plasmodium falciparum)
    - Interleukin-17 signaling (Plasmodium falciparum)
      - MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
- Innate Immune System (Plasmodium falciparum)
  - Toll-like Receptor Cascades (Plasmodium falciparum)
    - Toll Like Receptor 10 (TLR10) Cascade (Plasmodium falciparum)
      - MyD88 cascade initiated on plasma membrane (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 2 (TLR2) Cascade (Plasmodium falciparum)
      - Toll Like Receptor TLR1:TLR2 Cascade (Plasmodium falciparum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
      - Toll Like Receptor TLR6:TLR2 Cascade (Plasmodium falciparum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 3 (TLR3) Cascade (Plasmodium falciparum)
      - MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 4 (TLR4) Cascade (Plasmodium falciparum)
      - MyD88-independent TLR4 cascade (Plasmodium falciparum)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 5 (TLR5) Cascade (Plasmodium falciparum)
      - MyD88 cascade initiated on plasma membrane (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Plasmodium falciparum)
      - MyD88 dependent cascade initiated on endosome (Plasmodium falciparum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
    - Toll Like Receptor 9 (TLR9) Cascade (Plasmodium falciparum)
      - MyD88 dependent cascade initiated on endosome (Plasmodium falciparum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Plasmodium falciparum)
        
        MAP kinase activation (Plasmodium falciparum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Plasmodium falciparum)
        
        ERK/MAPK targets (Plasmodium falciparum)
        
        ERKs are inactivated (Plasmodium falciparum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Plasmodium falciparum)
        
        p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] (Plasmodium falciparum)
        
        p-T1218, Y220 MAPK7 dimer [nucleoplasm] (Plasmodium falciparum)
        
        Homologues of p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)
        
        phospho-p-T218,Y220-MAPK7 [nucleoplasm] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:C0H5B8

Reference Genes

ENSEMBL:PF3D7_1316000

PlasmoDB:PF3D7_1316000

Participant Of

hasMember

Homologues of p-T218,Y220-MAPK7 [nucleoplasm]

Other forms of this molecule

ub-MAPK6 [cytosol]

MAPK4 [nucleoplasm]

MAPK4 [cytosol]

MAPK6 [cytosol]

phospho-p-S189 MAPK6 [cytosol]

phospho-p-S186 MAPK4 [cytosol]

phospho-p-S186 MAPK4 [nucleoplasm]

phospho-p-S189 MAPK6 [nucleoplasm]

MAPK6 [nucleoplasm]

phospho-p-3S,T MAPK6 [nucleoplasm]

MAPK1 [azurophil granule lumen]

MAPK1 [ficolin-1-rich granule lumen]

MAPK14 [extracellular region]

MAPK14 [secretory granule lumen]

phospho-p-T180,Y182-MAPK13 [cytosol]

MAPK11 [cytosol]

MAPK13 [cytosol]

phospho-p-T185,Y187-MAPK1 [nucleoplasm]

phospho-p-T202,Y204-MAPK3 [nucleoplasm]

phospho-p-T221,Y223-MAPK10 [nucleoplasm]

phospho-p-T183,Y185-MAPK9 [nucleoplasm]

phospho-p-T,Y-MAPK8 [nucleoplasm]

phospho-p-T180,Y182-MAPK14 [nucleoplasm]

phospho-p-T180,Y182-MAPK11 [nucleoplasm]

MAPK14 [cytosol]

phospho-p-T185,Y187-MAPK1 [cytosol]

phospho-p-T202,Y204-MAPK3 [cytosol]

MAPK3 [cytosol]

phospho-p-T180,Y182-MAPK14 [cytosol]

MAPK3 [nucleoplasm]

MAPK1 [nucleoplasm]

MAPK11 [nucleoplasm]

phospho-p-T221,Y223-MAPK10 [cytosol]

phospho-p-T,Y-MAPK8 [cytosol]

phospho-p-T183,Y185-MAPK9 [cytosol]

MAPK9 [cytosol]

MAPK10 [cytosol]

MAPK8 [cytosol]

phospho-p-T218,Y220-MAPK7 [cytosol]

NLK [cytosol]

phospho-p-T298-NLK [cytosol]

phospho-p-T298-NLK [nucleoplasm]

phospho-p-T183,Y185-MAPK12 [cytosol]

MAPK12 [cytosol]

phospho-p-T180,Y182-MAPK11 [cytosol]

MAPK7 [nucleoplasm]

Inferred From

p-T218,Y220-MAPK7 [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-threonine at 218 (in Homo sapiens)

Coordinate

218

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 220 (in Homo sapiens)

Coordinate

220

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

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