Reactome | CHEK2 [nucleoplasm]

CHEK2 [nucleoplasm]

Stable Identifier

R-RNO-113824

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

Q9R019

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - G2/M DNA damage checkpoint (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)

DNA Repair (Rattus norvegicus)

- DNA Double-Strand Break Repair (Rattus norvegicus)
  - DNA Double Strand Break Response (Rattus norvegicus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        CHEK2 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9R019

Reference Genes

BioGPS Gene:114212

ENSEMBL:ENSRNOG00000037509

ENSEMBL:ENSRNOG00000037509.3

KEGG Gene (Rattus norvegicus):114212

Monarch:114212

NCBI Gene:114212

Reference Transcript

Other Identifiers

10762964

114212

1369010_at

17678957

5818705

5827628

5856741

5917927

5934486

5976388

6043983

6095337

6099421

6114404

6146367

6231705

6323787

6353928

6467908

6562583

6697961

A_42_P605265

A_44_P1032161

GE1106331

GE13370

GO:0003824

GO:0004672

GO:0005515

GO:0005524

GO:0006468

GO:0016740

GO:0036211

GO:0140096

ILMN_1370114

PH_rn_0010606

rc_AI071512_at

Participates

as an input of

CHEK2 is recruited to DNA DSBs (Rattus norvegicus)

as a component of

DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

phospho-p-T68-CHEK2 [nucleoplasm]

phospho-p-S,3T-CHEK2 [nucleoplasm]

Inferred From

CHEK2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_006249581.1, XP_006249582.1, XP_006249580.1, NP_446129.1, XP_006249583.1

Ensembl

ENSRNOT00000085591, ENSRNOG00000037509, ENSRNOP00000074651

RGD

621543