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phospho-p-S317,S345-CHEK1 [nucleoplasm]
Stable Identifier
R-RNO-113838
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Q91ZN7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G1/S DNA Damage Checkpoints (Rattus norvegicus)
p53-Independent G1/S DNA damage checkpoint (Rattus norvegicus)
p53-Independent DNA Damage Response (Rattus norvegicus)
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A (Rattus norvegicus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
Activation of ATR in response to replication stress (Rattus norvegicus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of Cdc25C at Ser 216 by Chk1 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Recruitment and activation of Chk1 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
G2/M DNA damage checkpoint (Rattus norvegicus)
CHEK1 phosphorylates TP53 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Recruitment and activation of Chk1 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
HDR through Homologous Recombination (HRR) (Rattus norvegicus)
Homologous DNA Pairing and Strand Exchange (Rattus norvegicus)
Presynaptic phase of homologous DNA pairing and strand exchange (Rattus norvegicus)
CHEK1 phosphorylates RAD51 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Processing of DNA double-strand break ends (Rattus norvegicus)
Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by E2F6 (Rattus norvegicus)
CHEK1 phosphorylates E2F6 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Activity through Phosphorylation (Rattus norvegicus)
CHEK1 phosphorylates TP53 (Rattus norvegicus)
phospho-p-S317,S345-CHEK1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q91ZN7
Reference Genes
BioGPS Gene:140583
ENSEMBL:ENSRNOG00000031896
ENSEMBL:ENSRNOG00000071217
ENSEMBL:ENSRNOG00055009175
ENSEMBL:ENSRNOG00060012193
ENSEMBL:ENSRNOG00065016588
KEGG:rno:140583
Monarch:140583
NCBI Gene:140583
UCSC:Q91ZN7
Reference Transcript
RefSeq:NM_080400.1
RefSeq:XM_008766042.2
RefSeq:XM_008766043.1
Other Identifiers
10916110
1387062_a_at
140583
17850971
5743778
5753726
5797227
5947504
5960887
5964461
6012187
6137001
6138195
6149664
6167249
6198329
6251914
6344066
6355854
6396448
6628688
6675234
6700100
GE1228389
GE17249
GO:0000077
GO:0000086
GO:0000228
GO:0000278
GO:0000781
GO:0000785
GO:0000794
GO:0001833
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006310
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0006974
GO:0006997
GO:0007010
GO:0007095
GO:0010468
GO:0010569
GO:0012501
GO:0016740
GO:0019904
GO:0023052
GO:0032991
GO:0035402
GO:0036211
GO:0042127
GO:0042770
GO:0043226
GO:0043231
GO:0044818
GO:0045787
GO:0045814
GO:0045839
GO:0046602
GO:0048856
GO:0071260
GO:0140014
GO:0140096
GO:1902742
PH_rn_0003033
Participates
as an output of
Recruitment and activation of Chk1 (Rattus norvegicus)
Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)
Other forms of this molecule
CHEK1 [cytosol]
CHEK1 [nucleoplasm]
Inferred From
p-S317,S345-CHEK1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 317 (in Homo sapiens)
Coordinate
317
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 345 (in Homo sapiens)
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_536325.1
,
XP_008764264.1
,
XP_008764265.1
ENSEMBL
ENSRNOT00000011226
,
ENSRNOP00000011226
IntEnz
2.7.11.1
PRO
Q91ZN7
RGD
620545
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