Reactome | Irs1 [cytosol]

Irs1 [cytosol]

Stable Identifier

R-RNO-1168867

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Insulin receptor substrate 1, IRS1_RAT, Irs1

External Reference Information

External Reference

UniProt:P35570 Irs1

Gene Names

Irs1, Irs-1

Chain

chain:1-1235

Reference Genes

BioGPS Gene:25467 Irs1

KEGG Gene (Rattus norvegicus):25467 Irs1

Monarch:25467 Irs1

NCBI Gene:25467 Irs1

UCSC:P35570 Irs1

Reference Transcript

RefSeq:NM_012969.1 Irs1

Participant Of

hasMember

Irs-1/2 [cytosol]

Other forms of this molecule

p-Y-Irs1 [cytosol]

phospho-p-6Y-IRS1 [plasma membrane]

IRS1 [plasma membrane]

IRS1 [cytosol]

phospho-p-Y-IRS1 [cytosol]

phospho-p-Y-IRS1 [plasma membrane]

Cross References

RefSeq

NP_037101.1

PRO

P35570

PDB

5WRK, 5WRM, 5WRL

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.791	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.737	5
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563)	0.656	3
UniProt:Q63787 Pik3r1	4	Pi3k-p85 [cytosol] (R-RNO-912643) K63polyUb-PIK3R1 [cytosol] (R-RNO-3080572) PIK3R1 [plasma membrane] (R-RNO-198365) PIK3R1 [cytosol] (R-RNO-74789)	0.589	2
UniProt:Q13625-2 TP53BP2			0.567	4
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.564	2
UniProt:P18031 PTPN1	1	PTPN1 [cytosol] (R-HSA-210625)	0.525	3
UniProt:Q8VDD9 PHIP			0.508	2
UniProt:P39688 Fyn	6	phospho-p-S21,Y420-FYN [cytosol] (R-MMU-5218745) MyrG,p-Y420-Fyn [plasma membrane] (R-MMU-9037733) pFyn(Y531) [cytosol] (R-MMU-420350) pFyn (420) [cytosol] (R-MMU-420335) Fyn [cytosol] (R-MMU-420333) phospho-MyrG-p-Y420-FYN-1 [plasma membrane] (R-MMU-9032530)	0.462	4

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