Prlr binds Stat5

Stable Identifier
R-RNO-1369093
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Prlr binds Stat5
PRLRs contain intracellular phosphorylated tyrosine residues that are able to bind and activate STATs, demonstrated by the co-immunoprecipitation of rat Prlr and Stat5 inPrlr mutants with a single intracellular tyrosine (Pezet et al. 1997). Prlr mutants with a single tyrosine residue at positions 599, 498 or 492 (reported as 580, 479 or 473 in Pezet et al. 1997) were all able to activate Stat5; Y599 gave a much stronger response. Short forms or Prlr lacking these tyrosines did not bind Stat5. Activation of Stat1 and Stat3 by Prlr has been reported (Da Silva et al. 1996) but the interaction has been suggested to be indirect and possibly mediated by Jak2.
Literature References
PubMed ID Title Journal Year
9312112 Tyrosine docking sites of the rat prolactin receptor required for association and activation of stat5

Ferrag, F, Edery, M, Kelly, PA, Pezet, A

J Biol Chem 1997
Participants
Orthologous Events
Authored
Reviewed
Created
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