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Amer1 [cytosol]
Stable Identifier
R-RNO-1504189
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
AMER1, D3ZCP6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
AXIN is phosphorylated in the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Assembly of the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Association of beta-catenin with the destruction complex (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Beta-catenin phosphorylation cascade (Rattus norvegicus)
Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Rattus norvegicus)
CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Rattus norvegicus)
p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Degradation of ubiquitinated beta catenin by the proteasome (Rattus norvegicus)
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Rattus norvegicus)
RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
Phosphorylation of APC component of the destruction complex (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Rattus norvegicus)
Beta-catenin is released from the destruction complex (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Amer1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:D3ZCP6
Gene Names
Amer1
Reference Genes
BioGPS Gene:501584 Amer1
ENSEMBL:ENSRNOG00000007984
ENSEMBL:ENSRNOG00000007984.7 Amer1
KEGG Gene (Rattus norvegicus):501584 Amer1
Monarch:501584 Amer1
NCBI Gene:501584 Amer1
Reference Transcript
RefSeq:NM_001109320.1 Amer1
Other Identifiers
10938485
17877895
501584
5636282
5717020
5754210
5817578
5839896
5901292
6010128
6070675
6079864
6166620
6210829
6502569
6577603
6610737
6624353
A_64_P043594
A_64_P043601
GO:0001822
GO:0005546
GO:0005634
GO:0005654
GO:0005886
GO:0008013
GO:0008289
GO:0016604
GO:0023052
GO:0030154
GO:0030163
GO:0031398
GO:0036211
GO:0043226
GO:0043231
GO:0045732
GO:0048856
GO:0060348
GO:0060612
GO:0060828
GO:0072161
GO:0090090
GO:0090263
GO:1904713
ILMN_1373208
PH_rn_0010752
Participates
as a component of
p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
as an input of
Assembly of the destruction complex (Rattus norvegicus)
as an output of
Beta-catenin is released from the destruction complex (Rattus norvegicus)
Inferred From
AMER1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001102790.1
Ensembl
ENSRNOT00000051132
,
ENSRNOP00000043681
,
ENSRNOG00000007984
RGD
1560322
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