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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
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Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
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Table of Contents
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phospho-p-Y542,Y580-PTPN11 [cytosol]
Stable Identifier
R-RNO-162573
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P41499
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by CSF3 (G-CSF) (Rattus norvegicus)
p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS (Rattus norvegicus)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-6 family signaling (Rattus norvegicus)
Interleukin-6 signaling (Rattus norvegicus)
PTPN11 is phosphorylated (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF-independent MAPK1/3 activation (Rattus norvegicus)
MAPK1 (ERK2) activation (Rattus norvegicus)
MAP2K2 binds MAPK1 (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
MAPK3 (ERK1) activation (Rattus norvegicus)
MAP2K1 binds MAPK3 (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
FRS-mediated FGFR1 signaling (Rattus norvegicus)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR1 signaling (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
FRS-mediated FGFR2 signaling (Rattus norvegicus)
Activated FGFR2 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
PI-3K cascade:FGFR2 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR2 signaling (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR2 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Ub-Activated FGFR2 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR2 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
FRS-mediated FGFR3 signaling (Rattus norvegicus)
Activated FGFR3 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
PI-3K cascade:FGFR3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR3 signaling (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Ub-Activated FGFR3 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
FRS-mediated FGFR4 signaling (Rattus norvegicus)
Activated FGFR4 phosphorylates PPTN11 (Rattus norvegicus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Rattus norvegicus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
PI-3K cascade:FGFR4 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Negative regulation of FGFR4 signaling (Rattus norvegicus)
CBL ubiquitinates FRS2 and FGFR4 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Ub-Activated FGFR4 complex:Ub-p-FRS2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p-CBL:GRB2 binds p-FRS2:activated FGFR4 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
GRB2 is indirectly recruited to p-KIT through SHP2 (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Indirect recruitment of GAB2 to p-KIT (Rattus norvegicus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Phosphorylation of SHP2 by SFKs (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
phospho-p-Y542,Y580-PTPN11 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P41499 Ptpn11
Gene Names
Ptpn11
Chain
initiator methionine:, chain:2-593
Reference Genes
BioGPS Gene:25622 Ptpn11
KEGG:rno:25622 Ptpn11
Monarch:25622 Ptpn11
NCBI Gene:25622 Ptpn11
UCSC:P41499 Ptpn11
Reference Transcript
RefSeq:NM_013088.2 Ptpn11
RefSeq:NM_001177593.1 Ptpn11
Participates
as a component of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:p-Y-SHC1:GRB2:p-Y643-GAB2:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
IL6:Tyrosine phosphorylated hexameric IL-6 receptor:Activated JAKs:p-Y546,Y584-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
p-Y-Shp2 [cytosol]
Ptpn11 [cytosol]
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
Inferred From
p-Y542,Y580-PTPN11 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 542 (in Homo sapiens)
Coordinate
542
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 580 (in Homo sapiens)
Coordinate
580
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_037220.2
,
NP_001171064.1
PRO
P41499
RGD
3447
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.59
4
UniProt:P97710 Sirpa
6
pSirpa_Rat [plasma membrane]
(R-RNO-548918)
Sirpa_Rat [plasma membrane]
(R-RNO-548921)
phospho-Sirpa [plasma membrane]
(R-RNO-391102)
Sirpa [tertiary granule membrane]
(R-RNO-6803288)
Sirpa [plasma membrane]
(R-RNO-3209922)
Sirpa [ficolin-1-rich granule membrane]
(R-RNO-6803321)
0.544
3
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