2 phosphorylated HSL monomers -> phosphorylated HSL dimer

Stable Identifier
R-RNO-163519
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
2 phosphorylated HSL monomers -> phosphorylated HSL dimer
While both monomeric and homodimeric forms of rat HSL protein have been detected, the predominant species, and the one with substantially greater catalytic activity when activated by phosphorylation, is the homodimer so HSL-mediated lipolysis is annotated in Reactome with dimeric phosphorylated enzyme as the catalyst. Phosphorylation appears to be required for dimerization to proceed (Shen et al. 2000).

Dimerization of human HSL has not been studied in detail, so the human reaction is inferred from the well-studied rat one.

Literature References
PubMed ID Title Journal Year
10694408 Hormone-sensitive lipase functions as an oligomer

Hong, R, Shen, WJ, Kraemer, FB, Patel, S

Biochemistry 2000
Participants
Orthologous Events
Authored
Created
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