Unknown carnitine exporter transports CAR from the cytosol to the extracellular space

Stable Identifier
R-RNO-165008
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
Synonyms
carnitine [cytosol] -> carnitine [extracellular]
General
SVG |   | PPTX  | SBGN
Unknown carnitine exporter transports CAR from the cytosol to the extracellular space

Studies of carnitine (CAR) export from intact rat liver indicate that this process is mediated by a specific, saturable transporter molecule (Sandor et al. 1985). The transporter itself has not been identified, but its properties are distinct from those of OCTN2, the major transport protein responsible for carnitine uptake (Kispal et al. 1987). The existence of a human transport reaction (again without an identified transporter) is inferred from the rat one.

Literature References
PubMed ID Title Journal Year
4005277 Release of carnitine from the perfused rat liver

Sandor, A, Kispal, G, Melegh, B, Alkonyi, I

Biochim Biophys Acta 1985
3024730 Enhanced uptake of carnitine by perfused rat liver following starvation

Kispal, G, Melegh, B, Alkonyi, I, Sandor, A

Biochim Biophys Acta 1987
Participants
Event Information
Catalyst Activity
Catalyst Activity
Title
carnitine transmembrane transporter activity of carnitine exporter [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created