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Myd88 [cytosol]
Stable Identifier
R-RNO-166059
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
MYD88, Q6Y1S1
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
Hyperphosphorylated IRAK1 associates with TRAF6 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP binds MYD88 homodimer (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 homodimer binds IRAK4 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IRAK1 binds to MYD88 within the IL1R complex (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IRAK4 is activated by autophosphorylation (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IRAK4 phosphorylates IRAK1 (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IRAK4-activated IRAK1 autophosphorylates (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
TRAF6 binding leads to IRAK1:TRAF6 release (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1 [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
The Interleukin 1 receptor complex binds Tollip (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer:TOLLIP [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:IRAK4:MYD88 dimer [plasma membrane] (Rattus norvegicus)
IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Cytosolic sensors of pathogen-associated DNA (Rattus norvegicus)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Rattus norvegicus)
DHX36 or DHX9 binds MyD88 (Rattus norvegicus)
DHX9/DHX36:CpG:MyD88 [cytosol] (Rattus norvegicus)
DHX36:CpG:MyD88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
DHX9:CpG:MyD88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)
DHX9:CpG:MyD88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
p-IRF7:p-IRF7 translocates to the nucleus (Rattus norvegicus)
DHX36:CpG:MyD88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
ZBP1(DAI) mediated induction of type I IFNs (Rattus norvegicus)
RIP-mediated NFkB activation via ZBP1 (Rattus norvegicus)
NFkB complex translocates from the cytosol to the nucleus (Rattus norvegicus)
DHX9:CpG:MyD88 [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IRAK interacts with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
MYD88 dissociates (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer:IRAK1,IRAK4,TRAF6 [plasma membrane] (Rattus norvegicus)
IL33:IL1RL1:IL1RAP-1:MYD88 dimer [plasma membrane] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Myd88 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q6Y1S1 Myd88
Gene Names
Myd88
Chain
chain:1-296
Reference Genes
BioGPS Gene:301059 Myd88
ENSEMBL:ENSRNOG00000013634.6 Myd88
KEGG Gene (Rattus norvegicus):301059 Myd88
Monarch:301059 Myd88
NCBI Gene:301059 Myd88
UCSC:Q6Y1S1 Myd88
Reference Transcript
RefSeq:NM_198130.1 Myd88
RefSeq:XM_006244087.3 Myd88
Other Identifiers
10920860
1374468_at
17856428
301059
5970240
6005486
6044740
6362051
6411479
6604717
6743979
A_44_P417916
A_64_P107866
GE16417
GO:0002238
GO:0002269
GO:0002283
GO:0002376
GO:0002755
GO:0003824
GO:0005149
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006325
GO:0006351
GO:0006355
GO:0006909
GO:0006915
GO:0006954
GO:0007165
GO:0007166
GO:0007254
GO:0009615
GO:0009682
GO:0009986
GO:0010467
GO:0010468
GO:0010628
GO:0012501
GO:0014004
GO:0016064
GO:0016071
GO:0016192
GO:0019897
GO:0022008
GO:0023052
GO:0030154
GO:0031234
GO:0031663
GO:0032481
GO:0032494
GO:0032496
GO:0032675
GO:0032680
GO:0032722
GO:0032731
GO:0032740
GO:0032747
GO:0032755
GO:0032757
GO:0032760
GO:0034142
GO:0034158
GO:0035325
GO:0035591
GO:0038172
GO:0042127
GO:0042742
GO:0042802
GO:0043123
GO:0043226
GO:0043588
GO:0043621
GO:0045944
GO:0046330
GO:0048856
GO:0048870
GO:0050671
GO:0050727
GO:0050830
GO:0051607
GO:0060090
GO:0060337
GO:0060907
GO:0065003
GO:0070498
GO:0070555
GO:0070935
GO:0070944
GO:0070976
GO:0071260
GO:0071310
GO:0090557
GO:0098542
GO:0140052
GO:0140096
GO:0140097
GO:0140104
GO:0140657
GO:0140674
GO:1900017
GO:1900227
GO:1902622
GO:2000338
GO:2000341
ILMN_1359024
PH_rn_0011962
Participates
as an input of
DHX36 or DHX9 binds MyD88 (Rattus norvegicus)
as a component of
DHX36:CpG:MyD88 [cytosol] (Rattus norvegicus)
DHX9:CpG:MyD88 [cytosol] (Rattus norvegicus)
MYD88 dimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
Myd88 [cytosol]
Inferred From
MYD88 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006244149.1
,
NP_937763.1
Ensembl
ENSRNOT00000018341
,
ENSRNOG00000013634
,
ENSRNOP00000018341
PRO
Q6Y1S1
RGD
735043
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