Reactome | Brk1 [cytosol]

Brk1 [cytosol]

Stable Identifier

R-RNO-1671645

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

BRK1, D3ZUP5

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
      - ABL phosphorylates WAVEs (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
      - p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Brk1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZUP5

Gene Names

Brk1

Reference Genes

BioGPS Gene:679934 Brk1

ENSEMBL:ENSRNOG00000010184

KEGG:rno:679934 Brk1

Monarch:679934 Brk1

NCBI Gene:679934 Brk1

UCSC:D3ZUP5 Brk1

Reference Transcript

RefSeq:NM_001195476.1 Brk1

Other Identifiers

10857883

1388854_at

17786158

5959419

5964442

6352605

6595482

679934

A_42_P496375

A_64_P133343

GE12824

GO:0001701

GO:0007010

GO:0007015

GO:0010592

GO:0016601

GO:0023052

GO:0030027

GO:0030036

GO:0031209

GO:0031267

GO:0031334

GO:0042802

GO:0044877

GO:0048144

GO:0048146

GO:0048856

GO:0048870

GO:0065003

GO:2000601

PH_rn_0016687

PH_rn_0019825

rc_AA944169_at

Participates

as a candidate of

RAC1 effectors [cytosol] (Rattus norvegicus)

as a component of

Inferred From

BRK1 [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOT00000013600, ENSRNOP00000013600, ENSRNOG00000010184

RGD

1598136

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