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RAF1 [cytosol]
Stable Identifier
R-RNO-167205
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P11345
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GP1b-IX-V activation signalling (Rattus norvegicus)
14-3-3-zeta binds Raf1 (Rattus norvegicus)
14-3-3-zeta:Raf1 [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
c-Src binds Raf1 (Rattus norvegicus)
Active c-Src:Raf1 [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Rap1 signalling (Rattus norvegicus)
Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
Rap1-GTP:Raf1 [plasma membrane] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Interferon Signaling (Rattus norvegicus)
Interferon gamma signaling (Rattus norvegicus)
IFNG signaling activates MAPKs (Rattus norvegicus)
Activated JAK1 binds RAF1 (Rattus norvegicus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
JAK1-mediated phosphorylation of RAF1 (Rattus norvegicus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CD209 (DC-SIGN) signaling (Rattus norvegicus)
PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)
p21 RAS:GTP:RAF1 [plasma membrane] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
RAF1 binds p21 RAS:GTP (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
p21 RAS:GTP:RAF1 [plasma membrane] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Stimuli-sensing channels (Rattus norvegicus)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Rattus norvegicus)
RAF1:SGK:TSC22D3:WPP [cytosol] (Rattus norvegicus)
RAF1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P11345 Raf1
Gene Names
Raf1, Raf
Chain
chain:1-648
Reference Genes
BioGPS Gene:24703 Raf1
KEGG:rno:24703 Raf1
Monarch:24703 Raf1
NCBI Gene:24703 Raf1
UCSC:P11345 Raf1
Reference Transcript
RefSeq:NM_012639.2 Raf1
Other Identifiers
10864738
1369932_a_at
17793960
24703
5636675
5648222
5665735
5667067
5717270
5754813
5777273
5806890
5820433
5827748
5858082
5876582
5879191
5997348
6144513
6221439
6343749
6348916
6436722
6517783
6687344
A_44_P409696
GE19876
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005524
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007010
GO:0007165
GO:0008285
GO:0008286
GO:0008625
GO:0012501
GO:0014044
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0033138
GO:0035019
GO:0035773
GO:0035994
GO:0036211
GO:0038133
GO:0042552
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0044342
GO:0045104
GO:0045944
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0060324
GO:0065003
GO:0071550
GO:0140096
GO:1902042
ILMN_1369837
M15427_s_at
M15428complete_seq_at
Participates
as an input of
Rap1 sequesters Raf1 to inhibit ERK cascade (Rattus norvegicus)
c-Src binds Raf1 (Rattus norvegicus)
14-3-3-zeta binds Raf1 (Rattus norvegicus)
RAF1 binds p21 RAS:GTP (Rattus norvegicus)
Activated JAK1 binds RAF1 (Rattus norvegicus)
as a component of
Rap1-GTP:Raf1 [plasma membrane] (Rattus norvegicus)
Active c-Src:Raf1 [cytosol] (Rattus norvegicus)
14-3-3-zeta:Raf1 [cytosol] (Rattus norvegicus)
RAF1:SGK:TSC22D3:WPP [cytosol] (Rattus norvegicus)
p21 RAS:GTP:RAF1 [plasma membrane] (Rattus norvegicus)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
phospho-p-S338-RAF1 [cytosol]
RAF proto-oncogene serine/threonine-protein kinase [cytosol]
p-S,T-Raf1 [cytosol]
phospho-hyperphosphorylated RAF1 [plasma membrane]
phospho-p-S621-RAF1 [plasma membrane]
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S259,S621-RAF1 [cytosol]
phospho-p-Y-RAF1 [cytosol]
Raf1 [cytosol]
phospho-p-S621-RAF1 [cytosol]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
Inferred From
RAF1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_036771.1
ENSEMBL
ENSRNOT00000109662
,
ENSRNOG00000010153
,
ENSRNOP00000092271
PRO
P11345
RGD
3531
PDB
1RRB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P29066
6
ARRB1 [cytoplasmic vesicle membrane]
(R-RNO-351187)
ARRB1 [Golgi membrane]
(R-RNO-350831)
ARRB1 [lysosomal membrane]
(R-RNO-432701)
ARRB1 [endocytic vesicle membrane]
(R-RNO-9910882)
PolyUb-ARRB1 [cytosol]
(R-RNO-6783186)
ARRB1 [cytosol]
(R-RNO-264470)
0.537
5
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