Reactome | Cd4 [plasma membrane]

Cd4 [plasma membrane]

Stable Identifier

R-RNO-167542

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

CD4, P05540

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 dileucine-containing cargo [plasma membrane] (Rattus norvegicus)
        
        Cd4 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P05540

Gene Names

Cd4

Reference Genes

BioGPS Gene:24932 Cd4

ENSEMBL:ENSRNOG00000016294

ENSEMBL:ENSRNOG00000016294 Cd4

KEGG Gene (Rattus norvegicus):24932 Cd4

Monarch:24932 Cd4

NCBI Gene:24932 Cd4

UCSC:P05540 Cd4

Reference Transcript

Other Identifiers

10865585

1369483_at

17794897

24932

5620623

5738990

5942189

5986969

5991411

6002086

6038973

6274421

6411147

6555776

6600382

6648950

6682372

A_43_P11522

A_64_P039482

GE19913

GO:0001816

GO:0001934

GO:0002250

GO:0002376

GO:0003674

GO:0005102

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005886

GO:0005887

GO:0006464

GO:0006810

GO:0006948

GO:0006950

GO:0006955

GO:0007155

GO:0007165

GO:0007166

GO:0008150

GO:0008270

GO:0008283

GO:0009058

GO:0009897

GO:0009986

GO:0010524

GO:0015026

GO:0016020

GO:0016021

GO:0019865

GO:0019899

GO:0019901

GO:0030154

GO:0030217

GO:0030225

GO:0032355

GO:0032507

GO:0033280

GO:0033674

GO:0034641

GO:0035397

GO:0035723

GO:0042011

GO:0042012

GO:0042102

GO:0042110

GO:0042289

GO:0042592

GO:0042802

GO:0042803

GO:0043123

GO:0043167

GO:0043226

GO:0043410

GO:0044403

GO:0045058

GO:0045121

GO:0045657

GO:0045860

GO:0045893

GO:0046598

GO:0048856

GO:0050731

GO:0050829

GO:0050850

GO:0050863

GO:0050870

GO:0051924

GO:0070374

GO:0097011

GO:1990782

ILMN_1368290

M15768_at

PH_rn_0011404

Participant Of

hasMember

AP-2 dileucine-containing cargo [plasma membrane]

input

hasComponent

Other forms of this molecule

Cd4 [clathrin-coated endocytic vesicle membrane]

Inferred From

CD4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_036837.1, XP_008761502.1, XP_006237393.1

Ensembl

ENSRNOT00000021915, ENSRNOP00000021915, ENSRNOG00000016294

PRO

P05540

RGD

2306

PDB

1CID

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