Reactome | Syt1 [plasma membrane]

Syt1 [plasma membrane]

Stable Identifier

R-RNO-168786

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

SYT1, P21707

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - STON2 binds SYT proteins (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        STON2,1:SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT dimers [plasma membrane] (Rattus norvegicus)
        
        SYT1 dimer [plasma membrane] (Rattus norvegicus)
        
        Syt1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P21707

Gene Names

Syt1

Reference Genes

BioGPS Gene:25716 Syt1

ENSEMBL:ENSRNOG00000006426

ENSEMBL:ENSRNOG00000006426 Syt1

KEGG Gene (Rattus norvegicus):25716 Syt1

Monarch:25716 Syt1

NCBI Gene:25716 Syt1

UCSC:P21707 Syt1

Reference Transcript

Other Identifiers

10902232

1373896_at

1384716_at

17835637

25716

5618059

5656998

5757254

5792944

5845065

5873976

5903616

5982731

5994826

6110424

6229945

6260178

6285663

6294382

6364909

6417990

6432383

6451288

6485830

6684034

6699105

A_42_P655441

A_44_P125913

A_44_P149993

GE1154650

GE1271718

GO:0000149

GO:0000902

GO:0001786

GO:0003674

GO:0005509

GO:0005513

GO:0005515

GO:0005516

GO:0005543

GO:0005544

GO:0005546

GO:0005575

GO:0005622

GO:0005737

GO:0005794

GO:0005886

GO:0006810

GO:0007267

GO:0007269

GO:0007420

GO:0008021

GO:0008022

GO:0008150

GO:0008289

GO:0014059

GO:0016020

GO:0016021

GO:0016079

GO:0016192

GO:0017075

GO:0017156

GO:0017158

GO:0019905

GO:0022607

GO:0030054

GO:0030141

GO:0030154

GO:0030276

GO:0030285

GO:0030348

GO:0030424

GO:0030658

GO:0030672

GO:0031045

GO:0031340

GO:0031410

GO:0033603

GO:0040007

GO:0042584

GO:0042734

GO:0042802

GO:0043005

GO:0043167

GO:0043195

GO:0043226

GO:0043229

GO:0044306

GO:0045202

GO:0045956

GO:0046872

GO:0046982

GO:0048278

GO:0048306

GO:0048488

GO:0048791

GO:0048856

GO:0050750

GO:0050806

GO:0051291

GO:0051592

GO:0051966

GO:0060076

GO:0061024

GO:0061669

GO:0061891

GO:0065003

GO:0070382

GO:0071277

GO:0071911

GO:0098746

GO:0098978

GO:0099502

GO:1903235

GO:1903305

GO:1903861

GO:2000300

ILMN_1357193

PH_rn_0010565

X52772cds_at

rc_AA943569_at

Participant Of

hasComponent

SYT1 dimer [plasma membrane]

output

Other forms of this molecule

Syt1 [clathrin-sculpted monoamine transport vesicle membrane]

Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]

Syt1 [clathrin-sculpted glutamate transport vesicle membrane]

Syt1 [clathrin-sculpted acetylcholine transport vesicle membrane]

Syt1 [clathrin-coated endocytic vesicle membrane]

Inferred From

SYT1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_017450168.1, NP_001028852.2

Ensembl

ENSRNOT00000048880, ENSRNOT00000088950, ENSRNOG00000006426, ENSRNOP00000049624, ENSRNOP00000069194

PRO

P21707

RGD

3803

PDB

1TJX, 5CCG, 1UOV, 5W5C, 5CCJ, 1RSY, 1TJM, 1UOW, 6MTI, 6CXW, 1K5W, 5CCI, 5W5D, 4WEE, 5CCH, 5KJ7, 5KJ8, 2YOA, 1BYN

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O35526 Stx1a	3	Syntaxin-1A [plasma membrane] (R-MMU-216884) Stx1a [cytosol] (R-MMU-9609866) Stx1a [plasma membrane] (R-MMU-449128)	0.623	3
UniProt:P63045	10	Vamp2 [plasma membrane] (R-RNO-210516) Vamp2 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-379363) Vamp2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-RNO-917738) Vamp2 [clathrin-sculpted glutamate transport vesicle membrane] (R-RNO-372517) Vamp2 [cytosol] (R-RNO-9609882) Vamp2 [lysosomal membrane] (R-RNO-432703) Vamp2 [Golgi membrane] (R-RNO-375425) Vamp2 [cytoplasmic vesicle membrane] (R-RNO-375436) Vamp2 [secretory granule membrane] (R-RNO-376363) Vamp2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869129)	0.609	7
UniProt:P50232 SYT4			0.602	3
UniProt:P18484 Ap2a2	8	Ap2a2 [secretory granule membrane] (R-RNO-6800412) Ap2a2 [endolysosome membrane] (R-RNO-6784819) Ap2a2 [ficolin-1-rich granule membrane] (R-RNO-6800414) Ap2a2 [endocytic vesicle membrane] (R-RNO-416635) Adaptor Protein 2 alpha 2 subunit [plasma membrane] (R-RNO-182073) Ap2a2 [plasma membrane] (R-RNO-177502) Ap2a2 [clathrin-coated endocytic vesicle membrane] (R-RNO-5138448) Ap2a2 [cytosol] (R-RNO-182155)	0.589	5
UniProt:P60879 Snap25			0.589	3
UniProt:Q00954 Scn1b	1	Sodium channel subunit beta-1 [plasma membrane] (R-RNO-373637)	0.544	2
copper(2+) [ChEBI:29036]	5	Cu2+ [Golgi lumen] (R-ALL-936901) Cu2+ [melanosome membrane] (R-ALL-5668569) Cu2+ [extracellular region] (R-ALL-437295) Cu2+ [mitochondrial intermembrane space] (R-ALL-3777113) Cu2+ [cytosol] (R-ALL-209799)	0.544	2

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