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SMURF2 [cytosol]
Stable Identifier
R-RNO-173537
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
F1M3F2
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Polyubiquitination of substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
E3:Ub:substrate [cytosol] (Rattus norvegicus)
E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
USP15 deubiquitinates SMAD1,SMAD2,SMAD3, SMAD7:SMURF,KEAP1 (Rattus norvegicus)
USP15:SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF2:TGFBR1 [cytosol] (Rattus norvegicus)
SMAD1,SMAD2,SMAD3,KEAP1,SMAD7:SMURF:TGFBR1 [cytosol] (Rattus norvegicus)
SMAD7:SMURF2:TGFBR1 [plasma membrane] (Rattus norvegicus)
SMAD7:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
USP15:Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Rattus norvegicus)
Ub-SMAD1,Ub-SMAD2,Ub-SMAD3,Ub-SMAD7:SMURF,Ub-KEAP1 [cytosol] (Rattus norvegicus)
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog 'on' state (Rattus norvegicus)
SMURF1/2 dissociates from ub-PTCH1 (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
ub-PTCH1:SMURF [ciliary membrane] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Signaling by TGF-beta family members (Rattus norvegicus)
Signaling by BMP (Rattus norvegicus)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Rattus norvegicus)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Rattus norvegicus)
I-SMAD:SMURF [cytosol] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
I-SMAD:SMURF [cytosol] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
TGF-beta receptor signaling activates SMADs (Rattus norvegicus)
Downregulation of TGF-beta receptor signaling (Rattus norvegicus)
SMURF2 binds SMAD2 (Rattus norvegicus)
SMAD2:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 ubiquitinates SMAD2 (Rattus norvegicus)
SMAD2:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Beta-catenin independent WNT signaling (Rattus norvegicus)
PCP/CE pathway (Rattus norvegicus)
Asymmetric localization of PCP proteins (Rattus norvegicus)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Rattus norvegicus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF1/2 ubiquitinates PRICKLE1 (Rattus norvegicus)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Degradation of AXIN (Rattus norvegicus)
AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)
AXIN:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
ub-AXIN:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 binds AXIN (Rattus norvegicus)
AXIN:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
Ubiquitinated AXIN is degraded by the proteasome (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
ub-AXIN:SMURF2 [cytosol] (Rattus norvegicus)
SMURF2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:F1M3F2
Reference Genes
ENSEMBL:ENSRNOG00000014623
ENSEMBL:ENSRNOG00000014623
Other Identifiers
10748361
10748363
1310067
1388607_at
1398420_at
17662546
303614
5627088
5687879
5693885
5700315
5700888
5733773
5865454
5907069
5935912
6025197
6027420
6058763
6136834
6328741
6417259
6562161
6636760
6711349
6723390
A_44_P234624
A_44_P825523
AABR07030590
AABR07030591
AABR07030592
ENSRNOG00000014623
ENSRNOP00000019781
ENSRNOT00000019781
EntrezGene:303614
EntrezGene:Smurf2
GE1138696
GE14515
GE18474
GO:0000003
GO:0000151
GO:0000209
GO:0003674
GO:0004842
GO:0005160
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0006464
GO:0006511
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0016567
GO:0016607
GO:0016740
GO:0030512
GO:0030514
GO:0030579
GO:0032991
GO:0034641
GO:0040011
GO:0042802
GO:0043161
GO:0043226
GO:0045732
GO:0046332
GO:0048856
GO:0048870
GO:0061630
GO:1901165
IPR000569
IPR001202
IPR024928
IPR035983
IPR036020
NM_001107061
NP_001100531
PF00397
PF00632
PH_rn_0009484
PH_rn_0022235
rc_AI177408_at
SM00119
SM00456
Smurf2
Smurf2-201
UPI00062E143F
XM_008768365
XM_017597342
XP_017452831
Participant Of
hasComponent
AXIN:SMURF2 [cytosol]
SMAD2:SMURF2 [cytosol]
SMAD7:SMURF2 [cytosol]
SMAD7:SMURF2:Ub-TGFBR1 [plasma membrane]
ub-AXIN:SMURF2 [cytosol]
hasMember
E3 ligases in proteasomal degradation [cytosol]
SMURF [cytosol]
output
SMURF2 ubiquitinates SMAD2
Ubiquitinated AXIN is degraded by the proteasome
input
SMURF2 binds AXIN
SMURF2 binds SMAD2
Other forms of this molecule
SMURF2 [nucleoplasm]
Inferred From
SMURF2 [cytosol] (Homo sapiens)
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