Endocytosis of clathrin-coated vesicle

Stable Identifier
R-RNO-182041
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Endocytosis of clathrin-coated vesicle

Dynamin is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. It is involved in vesicle trafficking processes and is necessary for endocytosis. Dynamins are large GTPases that bind to PIP2-containing membranes, several SH3-domain containing proteins and cytoskeletal modifiers. They self-polymerize in a GTP dependent manner, catalyzing the scission of invaginating membranes during endocytosis (Praefcke & McMahon, 2004). There are three dynamins in humans: dynamin I is neuron-specific; dynamin II shows ubiquitous expression; dynamin III is expressed in testis, brain, lung and blood platelets.

Literature References
PubMed ID Title Journal Year
10908605 Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation

Zhang, Y, Moheban, DB, Conway, BR, Bhattacharyya, A, Segal, RA

J Neurosci 2000
Participants
Catalyst Activity
Catalyst Activity
Title
GTPase activity of Dynamin1/2/3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Reviewed
Created