Reactome: A Curated Pathway Database

IP3 binds to the IP3 receptor, opening the Ca2+ channel

Stable Identifier
R-RNO-182052
Type
Reaction
Species
Rattus norvegicus
Compartment
Summation

The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.

Literature References
Participants
Orthologous Events