Reactome | Ap2a2 [cytosol]

Ap2a2 [cytosol]

Stable Identifier

R-RNO-182155

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

AP2A2(1-939), P18484

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Signaling by WNT (Rattus norvegicus)
  - Beta-catenin independent WNT signaling (Rattus norvegicus)
    - PCP/CE pathway (Rattus norvegicus)
      - WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Rattus norvegicus)
        
        FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Rattus norvegicus)
        
        clathrin:AP-2 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - WNT5A-dependent internalization of FZD4 (Rattus norvegicus)
        
        WNT5A:FZD4 is endocytosed (Rattus norvegicus)
        
        WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin:AP-2 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis (Rattus norvegicus)
        
        WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        clathrin:AP-2 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        clathrin:AP-2 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        AP2:chlorpromazine [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - AP2 binds chlorpromazine (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        AP2:chlorpromazine [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Dissociation of clathrin-associated proteins (Rattus norvegicus)
      - AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - FCHo proteins bind nascent clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Initial binding of AP-2 and clathrin to PI(4,5)P2 (Rattus norvegicus)
      - AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        Clathrin-coated vesicle [cytosol] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - Recruitment of AP-2 complex and clathrin (Rattus norvegicus)
      - AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:AP-2:clathrin [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)
        
        p-T156 AP-2 Complex [cytosol] (Rattus norvegicus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [cytosol] (Rattus norvegicus)
        
        Ap2a2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P18484 Ap2a2

Gene Names

Ap2a2, Adtab

Chain

initiator methionine:1, chain:2-938

Reference Genes

UCSC:P18484 Ap2a2

Participant Of

hasMember

Adaptor protein complex 2 (AP-2) large adaptins [cytosol]

Other forms of this molecule

Ap2a2 [endolysosome membrane]

Ap2a2 [ficolin-1-rich granule membrane]

Ap2a2 [secretory granule membrane]

Ap2a2 [endocytic vesicle membrane]

Ap2a2 [clathrin-coated endocytic vesicle membrane]

Adaptor Protein 2 alpha 2 subunit [plasma membrane]

Ap2a2 [plasma membrane]

Inferred From

AP2A2(1-939) [cytosol] (Homo sapiens)

Cross References

PRO

P18484

RGD

71015

PDB

6OWT, 6QH5, 2XA7, 2VGL, 4UQI, 6QH6, 4NEE, 6QH7

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88339	2	Epn1 [plasma membrane] (R-RNO-182952) Epn1 [cytosol] (R-RNO-8865826)	0.775	6
UniProt:P21707	6	Syt1 [plasma membrane] (R-RNO-168786) Syt1 [clathrin-sculpted monoamine transport vesicle membrane] (R-RNO-372508) Syt1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-RNO-917741) Syt1 [clathrin-sculpted glutamate transport vesicle membrane] (R-RNO-372514) Syt1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-RNO-210536) Syt1 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869113)	0.589	5

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