TrkA activation by adenosine A2a receptor

Stable Identifier
R-RNO-189618
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
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TrkA activation by adenosine A2a receptor

Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Adenosine (Ade-Rib), a neuromodulator acting through A2A receptors (ADORA2A), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, Ade-Rib binds ADORA2A and NTRK1 and NTRK2.

Literature References
PubMed ID Title Journal Year
11248116 Activation of Trk neurotrophin receptors in the absence of neurotrophins

Lee, FS, Chao, MV

Proc Natl Acad Sci U S A 2001
Participants
Catalyst Activity
Catalyst Activity
Title
G protein-coupled adenosine receptor activity of Adora2a [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Created