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p75NTR interacts with Irak:Myd88
Stable Identifier
R-RNO-193905
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
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SBGN
The serine/threonine kinase IRAK (interleukin-1 receptor-associated kinase) is necessary for NF-kB activation. Under basal conditions, IRAK is not bound to the p75 receptor, and stays inactive in the cytoplasm. It associates with p75NTR following neurotrophin binding. MYD88 functions as an adapter, by recruiting IRAK to the p75 receptor. Upon stimulation with NGF, a MYD88: IRAK1 complex quickly forms that is recruited to p75NTR.
Literature References
PubMed ID
Title
Journal
Year
12034707
Identification of interleukin 1 receptor-associated kinase as a conserved component in the p75-neurotrophin receptor activation of nuclear factor-kappa B
Wooten, MW
,
Mamidipudi, V
,
Li, X
J Biol Chem
2002
Participants
Input
Irak2:Myd88 [cytosol]
(Rattus norvegicus)
NGF ligand:p75NTR [plasma membrane]
(Rattus norvegicus)
Output
NGF ligand:p75NTR:Irak2:Myd88 [plasma membrane]
(Rattus norvegicus)
Orthologous Events
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-03-01)
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