Prdm4 (Sc1) binds to p75NTR

Stable Identifier
R-RNO-194493
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Prdm4 (Sc1) binds to p75NTR
PRDM4, usually named SC1, for Schwann Cell factor 1, is a zinc finger protein that functions as a repressor of transcription. It is present in many tissues, and abundant in brain. It interacts with the NGF:p75NTR complex to signal cell cycle arrest. It is unclear whether it already forms a complex with p75NTR before NGF binding to p75.
Literature References
PubMed ID Title Journal Year
10485890 Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor

Chittka, A, Chao, MV

Proc Natl Acad Sci U S A 1999
Participants
Input
Output
Orthologous Events
PRDM4 (SC1) binds to p75NTR (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-03-22)
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