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Axin1 [cytosol]
Stable Identifier
R-RNO-195249
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
AXIN1, O70239
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Signaling by WNT (Rattus norvegicus)
Degradation of beta-catenin by the destruction complex (Rattus norvegicus)
AXIN is phosphorylated in the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Assembly of the destruction complex (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
TCF dependent signaling in response to WNT (Rattus norvegicus)
Degradation of AXIN (Rattus norvegicus)
AXIN is ubiquitinated by SMURF2 (Rattus norvegicus)
AXIN:SMURF2 [cytosol] (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
SMURF2 binds AXIN (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
AXIN:SMURF2 [cytosol] (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Tankyrase ADP-ribosylates AXIN (Rattus norvegicus)
AXIN:TNKS [cytosol] (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Tankyrase binds AXIN (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
AXIN:TNKS [cytosol] (Rattus norvegicus)
AXIN [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Rattus norvegicus)
Beta-catenin is released from the destruction complex (Rattus norvegicus)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Rattus norvegicus)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Rattus norvegicus)
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
Axin1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O70239
Gene Names
Axin1
Reference Genes
BioGPS Gene:79257 Axin1
ENSEMBL:ENSRNOG00000062714
KEGG:rno:79257 Axin1
Monarch:79257 Axin1
NCBI Gene:79257 Axin1
UCSC:O70239 Axin1
Reference Transcript
RefSeq:NM_024405.1 Axin1
Participates
as an input of
Assembly of the destruction complex (Rattus norvegicus)
as a member of
AXIN [cytosol] (Rattus norvegicus)
as a component of
GSK3B:AXIN1 [cytosol] (Rattus norvegicus)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Axin1 [cytosol]
phospho-Axin1 [cytosol]
Axin1 [cytosol]
phospho-Axin1 [cytosol]
Inferred From
AXIN1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_077381.1
PRO
O70239
RGD
620859
PDB
2D5G
,
1WSP
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14640 DVL1
4
ub-DVL1 [cytosol]
(R-HSA-4641157)
DVL1 [cytosol]
(R-HSA-201687)
p-S-DVL1 [cytosol]
(R-HSA-201700)
pp-DVL1 [cytosol]
(R-HSA-3772396)
0.796
12
UniProt:O70239
5
phospho-Axin1 [cytosol]
(R-RNO-3640864)
phospho-Axin1 [cytosol]
(R-RNO-3640841)
Axin1 [cytosol]
(R-RNO-4641133)
phospho-Axin1 [cytosol]
(R-RNO-206040)
Axin1 [cytosol]
(R-RNO-195249)
0.729
5
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.602
12
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.591
7
UniProt:Q9Y4X0 AMMR1
0.499
3
IntAct:EBI-6876714 GSK3B
0.499
4
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [early endosome membrane]
(R-HSA-5368451)
0.463
5
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