Reactome | Gja1 [lysosomal membrane]

Gja1 [lysosomal membrane]

Stable Identifier

R-RNO-196173

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

lysosomal membrane

Synonyms

GJA1, P08050

Locations in the PathwayBrowser

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Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Gap junction trafficking and regulation (Rattus norvegicus)
    - Gap junction trafficking (Rattus norvegicus)
      - Gap junction degradation (Rattus norvegicus)
        
        Internalization of gap junction plaques (Rattus norvegicus)
        
        Invaginating gap junction plaques [lysosomal membrane] (Rattus norvegicus)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Rattus norvegicus)
        
        junctional plaque prior to invagination [lysosomal membrane] (Rattus norvegicus)
        
        gap junction plaque [lysosomal membrane] (Rattus norvegicus)
        
        Junctional channel [lysosomal membrane] (Rattus norvegicus)
        
        Hemi-channels [lysosomal membrane] (Rattus norvegicus)
        
        Connexin 43 hemi-channel [lysosomal membrane] (Rattus norvegicus)
        
        Gja1 [lysosomal membrane] (Rattus norvegicus)
        
        Lysosomal degradation of gap junction plaques (Rattus norvegicus)
        
        Invaginating gap junction plaques [lysosomal membrane] (Rattus norvegicus)
        
        planar gap junction plaques containing Dab2 [lysosomal membrane] (Rattus norvegicus)
        
        junctional plaque prior to invagination [lysosomal membrane] (Rattus norvegicus)
        
        gap junction plaque [lysosomal membrane] (Rattus norvegicus)
        
        Junctional channel [lysosomal membrane] (Rattus norvegicus)
        
        Hemi-channels [lysosomal membrane] (Rattus norvegicus)
        
        Connexin 43 hemi-channel [lysosomal membrane] (Rattus norvegicus)
        
        Gja1 [lysosomal membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P08050 Gja1

Gene Names

Gja1, Cxn-43

Chain

initiator methionine:1, chain:2-382

Reference Genes

BioGPS Gene:24392 Gja1

ENSEMBL:ENSRNOG00000000805 Gja1

KEGG Gene (Rattus norvegicus):24392 Gja1

Monarch:24392 Gja1

NCBI Gene:24392 Gja1

UCSC:P08050 Gja1

Reference Transcript

RefSeq:NM_012567.2 Gja1

Other Identifiers

10830189

1369640_at

1372002_at

17755182

24392

5994774

6056045

6107686

A_44_P393551

GE1202712

GE15258

GE19827

GO:0005215

GO:0005886

GO:0005922

GO:0007154

GO:0007267

GO:0007507

GO:0022857

GO:0023052

GO:0032991

GO:0048856

GO:0055085

ILMN_1355543

PH_rn_0012295

rc_AA858448_at

rc_AI029183_s_at

Participates

as a component of

Connexin 43 hemi-channel [lysosomal membrane] (Rattus norvegicus)

Other forms of this molecule

Cx43 [plasma membrane]

Connexin 43 [Golgi membrane]

Cx43 [endoplasmic reticulum membrane]

Gja1 [Golgi membrane]

Gja1 [endoplasmic reticulum membrane]

phospho-Gja1 [plasma membrane]

Gja1 [plasma membrane]

Cx43 [Golgi-associated vesicle membrane]

Gja1 [Golgi-associated vesicle membrane]

Inferred From

GJA1 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

NP_036699.1

Ensembl

ENSRNOP00000001054, ENSRNOT00000001054, ENSRNOG00000000805

PRO

P08050

RGD

2690

PDB

1R5S, 3CYY, 2N8T

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8VCZ6 SGSM3			0.602	4
UniProt:P68254 Ywhaq	1	14-3-3 theta [cytosol] (R-MMU-1445117)	0.527	2
UniProt:Q63664	1	Kcnj8 [plasma membrane] (R-RNO-265575)	0.524	4
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.489	2
UniProt:Q07157 TJP1	5	TJP1 [cell junction] (R-HSA-8936023) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [cytosol] (R-HSA-532659)	0.463	2