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phospho-p-T308,S473-AKT1 [cytosol]
Stable Identifier
R-RNO-198356
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P47196
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1/S Transition (Rattus norvegicus)
Cyclin E associated events during G1/S transition (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
S Phase (Rattus norvegicus)
Cyclin A:Cdk2-associated events at S phase entry (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
NFE2L2 translocates from cytosol to nucleoplasm (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
AKT interacts and phosphorylates Cot (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
CTLA4 inhibitory signaling (Rattus norvegicus)
Dephosphorylation of AKT by PP2A (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
eNOS activation (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Uncoupled eNOS favours the formation of superoxide (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of cofactors (Rattus norvegicus)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Metabolism of RNA (Rattus norvegicus)
Regulation of mRNA stability by proteins that bind AU-rich elements (Rattus norvegicus)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (Rattus norvegicus)
Protein Kinase B/Akt phosphorylates BRF1 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
KSRP (KHSRP) binds and destabilizes mRNA (Rattus norvegicus)
Protein Kinase B (AKT) phosphorylates KSRP (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
AKT phosphorylates targets in the cytosol (Rattus norvegicus)
AKT phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates IKKalpha (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates MDM2 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates MKRN1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates TSC2, inhibiting it (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates caspase-9 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT phosphorylates p21Cip1 and p27Kip1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PHLPP dephosphorylates S473 in AKT (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN stability and activity (Rattus norvegicus)
AKT phosphorylates MKRN1 (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by NOTCH (Rattus norvegicus)
Signaling by NOTCH4 (Rattus norvegicus)
Negative regulation of NOTCH4 signaling (Rattus norvegicus)
AKT1 phosphorylates NOTCH4 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
Downregulation of ERBB2 signaling (Rattus norvegicus)
Downregulation of ERBB2:ERBB3 signaling (Rattus norvegicus)
Phosphorylation of USP8 by P-AKT (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
AKT1 phosphorylates eNOS (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
eNOS synthesizes NO (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Rab regulation of trafficking (Rattus norvegicus)
RAB GEFs exchange GTP for GDP on RABs (Rattus norvegicus)
Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling (Rattus norvegicus)
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
phospho-p-T308,S473-AKT1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P47196 Akt1
Gene Names
Akt1
Chain
chain:1-480
Reference Genes
BioGPS Gene:24185 Akt1
KEGG Gene (Rattus norvegicus):24185 Akt1
Monarch:24185 Akt1
NCBI Gene:24185 Akt1
UCSC:P47196 Akt1
Reference Transcript
RefSeq:NM_033230.2 Akt1
RefSeq:XM_006240631.2 Akt1
Other Identifiers
10892316
1368862_at
1383126_at
17824513
24185
5740093
5740257
5748305
5752488
5776417
5850193
6072712
6094433
6104319
6172107
6193924
6383255
6728783
A_44_P282433
D30040_at
GE12234
GE19486
GO:0000166
GO:0000278
GO:0001649
GO:0001893
GO:0001934
GO:0001938
GO:0002042
GO:0002376
GO:0002931
GO:0003013
GO:0003376
GO:0004672
GO:0004674
GO:0004712
GO:0005080
GO:0005515
GO:0005516
GO:0005524
GO:0005547
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005929
GO:0005975
GO:0005977
GO:0005978
GO:0005979
GO:0006006
GO:0006091
GO:0006351
GO:0006355
GO:0006412
GO:0006417
GO:0006468
GO:0006469
GO:0006606
GO:0006629
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0006924
GO:0006954
GO:0006974
GO:0006979
GO:0007005
GO:0007155
GO:0007165
GO:0007173
GO:0007249
GO:0007281
GO:0007399
GO:0007568
GO:0008284
GO:0008286
GO:0008289
GO:0008637
GO:0008643
GO:0009408
GO:0009725
GO:0010033
GO:0010467
GO:0010507
GO:0010595
GO:0010628
GO:0010629
GO:0010748
GO:0010763
GO:0010765
GO:0010907
GO:0010918
GO:0010951
GO:0010975
GO:0012501
GO:0014065
GO:0016020
GO:0016301
GO:0016310
GO:0016567
GO:0016740
GO:0018105
GO:0018107
GO:0019899
GO:0019901
GO:0021510
GO:0022414
GO:0023052
GO:0030030
GO:0030154
GO:0030163
GO:0030235
GO:0030307
GO:0030334
GO:0031397
GO:0031641
GO:0031663
GO:0031982
GO:0031999
GO:0032079
GO:0032091
GO:0032094
GO:0032287
GO:0032436
GO:0032794
GO:0032869
GO:0032880
GO:0032929
GO:0032991
GO:0033138
GO:0034405
GO:0034614
GO:0035556
GO:0035655
GO:0035924
GO:0036064
GO:0036211
GO:0036294
GO:0038061
GO:0042593
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043066
GO:0043154
GO:0043161
GO:0043226
GO:0043325
GO:0043491
GO:0043536
GO:0045429
GO:0045600
GO:0045725
GO:0045737
GO:0045792
GO:0045861
GO:0045893
GO:0045907
GO:0045944
GO:0046326
GO:0046329
GO:0046622
GO:0046889
GO:0048009
GO:0048266
GO:0048661
GO:0048856
GO:0048870
GO:0051000
GO:0051091
GO:0051146
GO:0051247
GO:0051721
GO:0055085
GO:0060416
GO:0060709
GO:0060716
GO:0061024
GO:0070141
GO:0070848
GO:0071260
GO:0071276
GO:0071356
GO:0071363
GO:0071364
GO:0071380
GO:0071407
GO:0071456
GO:0071889
GO:0072655
GO:0072656
GO:0072659
GO:0090201
GO:0097011
GO:0097194
GO:0098772
GO:0099104
GO:0106310
GO:0110099
GO:0140052
GO:0140096
GO:1900087
GO:1900182
GO:1901653
GO:1903038
GO:1903078
GO:1903715
GO:1903721
GO:1990090
GO:1990418
GO:2000010
GO:2000402
GO:2001243
rc_AA799664_at
Participates
as an input of
AKT1 binds eNOS complex via HSP90 (Rattus norvegicus)
AKT1 dephosphorylation by PP2A-B56-beta,gamma (Rattus norvegicus)
as a component of
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Rattus norvegicus)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Rattus norvegicus)
as a member of
p-T,p-S-AKT [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-T308,S473-AKT1 [plasma membrane]
phospho-p-Y315,Y326-AKT1 [cytosol]
phospho-p-T308-AKT1 [cytosol]
Phospho-Akt1 [nucleoplasm]
Phospho-Akt1 [cytosol]
Akt1 [cytosol]
AKT1 [plasma membrane]
phospho-p-S473-AKT1 [plasma membrane]
phospho-p-T308,S473-AKT1 [nucleoplasm]
Inferred From
p-T308,S473-AKT1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 308
Coordinate
308
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 473
Coordinate
473
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_150233.1
,
XP_006240693.1
IntEnz
2.7.11.1
Ensembl
ENSRNOG00000028629
,
ENSRNOT00000031164
,
ENSRNOP00000038369
PRO
P47196
RGD
2081
HMDB Protein
HMDBP13421
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q63369 NFKB1
0.61
9
UniProt:P84025
9
Ub-SMAD3 [cytosol]
(R-RNO-6782830)
phospho-p-S208-SMAD3 [cytosol]
(R-RNO-9731114)
SMAD3 [nucleoplasm]
(R-RNO-206150)
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2187326)
phospho-Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-9773841)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-RNO-2176471)
SMAD3 [cytosol]
(R-RNO-170855)
phospho-p-S423,S425-SMAD3 [cytosol]
(R-RNO-171184)
phospho-p-S423,S425-SMAD3 [nucleoplasm]
(R-RNO-177104)
0.524
4
UniProt:O70436
8
Ub-SMAD2 [cytosol]
(R-RNO-6782774)
phospho-p-S250-SMAD2 [cytosol]
(R-RNO-9731121)
SMAD2 [nucleoplasm]
(R-RNO-3006352)
phospho-Ub,p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-9773843)
phospho-p-T220,S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009189)
SMAD2 [cytosol]
(R-RNO-3006353)
phospho-p-S465,S467-SMAD2 [cytosol]
(R-RNO-3009186)
phospho-p-S465,S467-SMAD2 [nucleoplasm]
(R-RNO-3009185)
0.524
2
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