Akt1 phosphorylates GSK3

Stable Identifier
R-RNO-198601
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Akt1 phosphorylates GSK3
GSK3 (glycogen synthase kinase-3) participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, and the transcription factors MYB and JUN. GSK3 phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. GSK3 is inhibited when phosphorylated by AKT1.
Literature References
PubMed ID Title Journal Year
8524413 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, DA, Alessi, DR, Cohen, P, Andjelkovich, M, Hemmings, BA

Nature 1995
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Phospho-Akt1 [cytosol]

Physical Entity
Phospho-Akt1 [cytosol] (Rattus norvegicus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT phosphorylates GSK3 (Homo sapiens)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-29)
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