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phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm]
Stable Identifier
R-RNO-199829
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Q63531
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular Senescence (Rattus norvegicus)
Senescence-Associated Secretory Phenotype (SASP) (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
MITF-M-regulated melanocyte development (Rattus norvegicus)
Transcriptional and post-translational regulation of MITF-M expression and activity (Rattus norvegicus)
RPS6KA1-dependent phosphorylation of MITF-M (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
MAPK targets/ Nuclear events mediated by MAP kinases (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
Post NMDA receptor activation events (Rattus norvegicus)
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling (Rattus norvegicus)
Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs) (Rattus norvegicus)
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
RSK activation (Rattus norvegicus)
p-S363,S380,T573 RS6K translocates to the nucleus (Rattus norvegicus)
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
Gastrin-CREB signalling pathway via PKC and MAPK (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Nuclear Events (kinase and transcription factor activation) (Rattus norvegicus)
CREB phosphorylation (Rattus norvegicus)
RSK1/2/3 phosphorylates CREB at Serine 119 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
ERK/MAPK targets (Rattus norvegicus)
ERK1/2/5 activate RSK1/2/3 (Rattus norvegicus)
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q63531 Rps6ka1
Gene Names
Rps6ka1, Mapkapk1a, Rsk1
Chain
chain:1-735
Reference Genes
BioGPS Gene:81771 Rps6ka1
KEGG Gene (Rattus norvegicus):81771 Rps6ka1
Monarch:81771 Rps6ka1
NCBI Gene:81771 Rps6ka1
UCSC:Q63531 Rps6ka1
Reference Transcript
RefSeq:NM_031107.1 Rps6ka1
Participates
as a member of
Phospho-Ribosomal protein S6 kinase [nucleoplasm] (Rattus norvegicus)
p-S221,T359,S363,S380,T573,T732-RSK [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
RPS6KA1 [nucleoplasm]
p-T359,S363,S380,T573,T732-Rps6ka1 [cytosol]
p-T359,S363,T573-Rps6ka1 [cytosol]
Rps6ka1 [cytosol]
phospho-p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
Inferred From
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(Homo sapiens)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 221 (in Homo sapiens)
Coordinate
221
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 363
Coordinate
363
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 380
Coordinate
380
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 732 (in Homo sapiens)
Coordinate
732
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 359
Coordinate
359
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 573
Coordinate
573
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_112369.1
PRO
Q63531
RGD
620675
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