Reactome | Nckap1 [cytosol]

Nckap1 [cytosol]

Stable Identifier

R-RNO-200979

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

NCKAP1, P55161

Locations in the PathwayBrowser

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Immune System (Rattus norvegicus)

- Innate Immune System (Rattus norvegicus)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
    - Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
      - (WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
      - ABL phosphorylates WAVEs (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
      - Detachment of WASP/WAVE (Rattus norvegicus)
        
        Mother filament:branching complex [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        WAVE2, WASP, N-WASP [plasma membrane] (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        WAVE Regulatory Complex [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
      - p-ERK phosphorylates WAVEs and ABI (Rattus norvegicus)
        
        p-Y,S,T-WRC:IRSp53/58:RAC1:GTP:PIP3 [cytosol] (Rattus norvegicus)
        
        p-Y,S,T-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)
        
        p-Y-WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Rattus norvegicus)
        
        p-Y-WRC [cytosol] (Rattus norvegicus)
        
        Nckap1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P55161

Gene Names

Nckap1

Reference Genes

BioGPS Gene:58823 Nckap1

ENSEMBL:ENSRNOG00000007518

KEGG:rno:58823 Nckap1

Monarch:58823 Nckap1

NCBI Gene:58823 Nckap1

UCSC:P55161 Nckap1

Reference Transcript

RefSeq:NM_031618.1 Nckap1

Participates

as a candidate of

RAC2 plasma membrane effectors [cytosol] (Rattus norvegicus)

as a component of

Inferred From

NCKAP1 [cytosol] (Homo sapiens)

Cross References

PRO

P55161

GlyGen

P55161

RGD

61939

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