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PARP1 [nucleoplasm]
Stable Identifier
R-RNO-201568
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
P27008
Locations in the PathwayBrowser
Expand all
DNA Repair (Rattus norvegicus)
Base Excision Repair (Rattus norvegicus)
Resolution of Abasic Sites (AP sites) (Rattus norvegicus)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Rattus norvegicus)
POLB-Dependent Long Patch Base Excision Repair (Rattus norvegicus)
PARG dePARylates PARP1,PARP2 (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
POLB-mediated DNA strand displacement synthesis (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through MMEJ (alt-NHEJ) (Rattus norvegicus)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Rattus norvegicus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Rattus norvegicus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Rattus norvegicus)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Nucleotide Excision Repair (Rattus norvegicus)
Global Genome Nucleotide Excision Repair (GG-NER) (Rattus norvegicus)
DNA Damage Recognition in GG-NER (Rattus norvegicus)
PARP1 or PARP2 PARylates DDB2 and autoPARylates (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 or PARP2 binds DDB2 at GG-NER site (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:UV-DDB:PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 dimers [nucleoplasm] (Rattus norvegicus)
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
SUMOylation (Rattus norvegicus)
SUMO E3 ligases SUMOylate target proteins (Rattus norvegicus)
SUMOylation of DNA damage response and repair proteins (Rattus norvegicus)
PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
PARP1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P27008
Reference Genes
BioGPS Gene:25591
ENSEMBL:ENSRNOG00000003084
ENSEMBL:ENSRNOG00000003084.6
ENSEMBL:ENSRNOG00055012447
ENSEMBL:ENSRNOG00060006959
ENSEMBL:ENSRNOG00065024216
KEGG Gene (Rattus norvegicus):25591
Monarch:25591
NCBI Gene:25591
UCSC:P27008
Reference Transcript
RefSeq:NM_013063.2
Other Identifiers
10766170
1369969_at
17682574
25591
5735855
5752547
5868844
5879717
5996373
6023511
6062384
6064649
6067711
6072584
6146465
6199362
6206775
6216932
6248190
6265232
6283938
6296963
6319909
6381427
6432062
6433915
6443270
6504614
6545125
6551318
6604760
A_43_P11687
A_44_P1033023
GE20148
GE22073
GO:0000122
GO:0000228
GO:0000785
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003824
GO:0003950
GO:0005634
GO:0005635
GO:0005654
GO:0005667
GO:0005694
GO:0005730
GO:0005739
GO:0005829
GO:0006260
GO:0006281
GO:0006302
GO:0006310
GO:0006351
GO:0006355
GO:0006915
GO:0006974
GO:0007005
GO:0008270
GO:0012501
GO:0016604
GO:0016740
GO:0019899
GO:0019901
GO:0023052
GO:0030592
GO:0031491
GO:0032042
GO:0032786
GO:0032869
GO:0032880
GO:0032991
GO:0032993
GO:0034244
GO:0034599
GO:0034644
GO:0035861
GO:0036211
GO:0042802
GO:0042803
GO:0043123
GO:0043226
GO:0043504
GO:0043596
GO:0045824
GO:0045944
GO:0051287
GO:0055086
GO:0061629
GO:0071168
GO:0071932
GO:0090734
GO:0098542
GO:0140096
GO:0140294
GO:0140805
GO:0140806
GO:0140807
GO:0140808
GO:0140815
GO:0140816
GO:0140817
GO:0160049
GO:1901135
GO:1903518
GO:1905051
GO:1905168
GO:1990404
GO:1990966
GO:2001170
ILMN_1360864
PH_rn_0010974
U94340_at
rc_AA964849_at
Participates
as an input of
PIAS4 SUMOylates PARP1 with SUMO2,3 (Rattus norvegicus)
PIAS4 SUMOylates PARP1 with SUMO1 (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
as a member of
PARP1,PARP2 [nucleoplasm] (Rattus norvegicus)
as an output of
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
as a component of
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
PAR-PARP1 [nucleoplasm]
Inferred From
PARP1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_037195.1
ZINC - Substances
PARP1_RAT
Ensembl
ENSRNOT00000004232
,
ENSRNOG00000003084
,
ENSRNOP00000004232
ZINC target
P27008
PRO
P27008
RGD
2053
ZINC - Predictions - Purchasable
PARP1_RAT
PDB
2LE0
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