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Ptk2 [cytosol]
Stable Identifier
R-RNO-201621
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
PTK2, O35346
Locations in the PathwayBrowser for interactor UniProt:Q6P6T5"
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Apoptotic execution phase (Rattus norvegicus)
Apoptotic cleavage of cellular proteins (Rattus norvegicus)
Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
PTK2 binds activated EGFR (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates PTK2 signaling (Rattus norvegicus)
PTK2 binds activated MET (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
Ptk2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O35346 Ptk2
Gene Names
Ptk2, Fak, Fak1
Chain
initiator methionine:1, chain:2-1055
Reference Genes
BioGPS Gene:25614 Ptk2
ENSEMBL:ENSRNOG00000007916 Ptk2
KEGG Gene (Rattus norvegicus):25614 Ptk2
Monarch:25614 Ptk2
NCBI Gene:25614 Ptk2
UCSC:O35346 Ptk2
Reference Transcript
RefSeq:NM_013081.2 Ptk2
Other Identifiers
10904377
1387875_at
17837998
25614
5659624
5665959
5712630
5773281
5821195
5826568
5842671
5849663
5887928
5944013
5956197
5979179
5986212
6012594
6023197
6031852
6145232
6161480
6197618
6221112
6226271
6240955
6293395
6296857
6326956
6352731
6412633
6425388
6470543
6511075
6525621
6590606
6726475
6746691
A_44_P1006377
A_44_P1045425
A_44_P510809
A_44_P667865
A_44_P836576
A_44_P868335
GE20162
GO:0000165
GO:0000166
GO:0000226
GO:0000902
GO:0001525
GO:0001568
GO:0001570
GO:0001725
GO:0001764
GO:0001932
GO:0001934
GO:0002376
GO:0003013
GO:0003674
GO:0003779
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005178
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005929
GO:0006464
GO:0006468
GO:0006810
GO:0006914
GO:0006950
GO:0007010
GO:0007097
GO:0007155
GO:0007165
GO:0007169
GO:0007172
GO:0007173
GO:0007179
GO:0007229
GO:0007254
GO:0007267
GO:0007275
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008360
GO:0008432
GO:0009056
GO:0009612
GO:0009749
GO:0010033
GO:0010243
GO:0010507
GO:0010613
GO:0010632
GO:0010759
GO:0010763
GO:0014068
GO:0014070
GO:0014704
GO:0014911
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016604
GO:0016740
GO:0018108
GO:0019899
GO:0019901
GO:0019902
GO:0019903
GO:0021955
GO:0022408
GO:0022607
GO:0030027
GO:0030054
GO:0030154
GO:0030155
GO:0030198
GO:0030307
GO:0030335
GO:0030336
GO:0030644
GO:0031234
GO:0031625
GO:0032355
GO:0033628
GO:0034330
GO:0036064
GO:0038083
GO:0040007
GO:0040011
GO:0042127
GO:0042169
GO:0042383
GO:0042493
GO:0042592
GO:0042802
GO:0042995
GO:0043066
GO:0043167
GO:0043197
GO:0043226
GO:0043542
GO:0043548
GO:0044877
GO:0045087
GO:0045444
GO:0045667
GO:0045785
GO:0045860
GO:0046621
GO:0046685
GO:0046777
GO:0048013
GO:0048471
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050766
GO:0050771
GO:0050806
GO:0051893
GO:0051897
GO:0051964
GO:0060252
GO:0060396
GO:0065003
GO:0071560
GO:0090303
GO:0097755
GO:0098794
GO:0098978
GO:0120041
GO:1900024
GO:2000060
GO:2000811
S83358_s_at
Participant Of
input
Caspase-mediated cleavage of FADK 1
PTK2 binds activated EGFR
PTK2 binds activated MET
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2
Translocation of PTK2 to Focal complexes
hasComponent
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane]
HGF:p-4Y-MET dimer:PTK2 [plasma membrane]
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane]
hasMember
Src-kinases [cytosol]
Other forms of this molecule
FAK1_RAT [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
Ptk2 [cytosol]
Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
phospho-Ptk2 [cytosol]
Inferred From
PTK2 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_037213.1
ZINC target
O35346
Ensembl
ENSRNOG00000007916
,
ENSRNOP00000011219
,
ENSRNOT00000011219
PRO
O35346
RGD
3443
ZINC - Predictions - Purchasable
FAK1_RAT
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35346 Ptk2
12
phospho-Ptk2 [cytosol]
(R-RNO-9632393)
FAK1_RAT [cytosol]
(R-RNO-548922)
phospho-Ptk2 [cytosol]
(R-RNO-8874613)
phospho-Ptk2 [cytosol]
(R-RNO-8874600)
Ptk2 [cytosol]
(R-RNO-202829)
Ptk2 [cytosol]
(R-RNO-202827)
phospho-Ptk2 [cytosol]
(R-RNO-5218711)
phospho-Ptk2 [cytosol]
(R-RNO-5229006)
phospho-Ptk2 [cytosol]
(R-RNO-5218694)
Ptk2 [cytosol]
(R-RNO-201621)
phospho-Ptk2 [cytosol]
(R-RNO-354068)
phospho-Ptk2 [cytosol]
(R-RNO-354128)
0.722
12
UniProt:Q6P6T5
3
Ocln [plasma membrane]
(R-RNO-351873)
Ocln [plasma membrane]
(R-RNO-351854)
Ocln [plasma membrane]
(R-RNO-351846)
0.589
2
UniProt:Q5XI86
2
Ptrh2 [mitochondrial outer membrane]
(R-RNO-6783190)
Ptrh2 [mitochondrial outer membrane]
(R-RNO-5696909)
0.463
3
UniProt:Q8VI36
4
Pxn [plasma membrane]
(R-MMU-180493)
phospho-Pxn [plasma membrane]
(R-MMU-9031680)
Pxn [cytosol]
(R-MMU-210014)
phospho-Pxn [cytosol]
(R-MMU-5218693)
0.463
2
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