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Wasl [cytosol]
Stable Identifier
R-RNO-201873
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
N-WASP, O08816
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Rattus norvegicus)
Nephrin family interactions (Rattus norvegicus)
Nephrin mediated activation of N-WASP (Rattus norvegicus)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
CDC42 and PIP2 bind WASL, activating it (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Rattus norvegicus)
ITSN1:N-WASP [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Rattus norvegicus)
ITSN1:N-WASP [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
N-WASP binds ARP2/3 and G-actin (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Rattus norvegicus)
ITSN1:N-WASP [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Rattus norvegicus)
p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Rattus norvegicus)
ITSN1:N-WASP [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Netrin-1 signaling (Rattus norvegicus)
DCC mediated attractive signaling (Rattus norvegicus)
Recruitment and activation of N-WASP by Cdc42 (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Src phosphorylate WASP,N-WASP (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
WIP binds WASP,N-WASP, activating them (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of nitric oxide: NOS3 activation and regulation (Rattus norvegicus)
NOSTRIN mediated eNOS trafficking (Rattus norvegicus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
Src phosphorylate WASP,N-WASP (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
WIP binds WASP,N-WASP, activating them (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Vesicle-mediated transport (Rattus norvegicus)
Membrane Trafficking (Rattus norvegicus)
Clathrin-mediated endocytosis (Rattus norvegicus)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
BAR domain proteins recruit dynamin (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Dissociation of clathrin-associated proteins (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
WASL,CTTN [cytosol] (Rattus norvegicus)
Wasl [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O08816 Wasl
Gene Names
Wasl
Chain
initiator methionine:1, chain:2-501
Reference Genes
UCSC:O08816 Wasl
Participant Of
hasMember
WASL,CTTN [cytosol]
input
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP
Nephrin mediated activation of N-WASP
Recruitment and activation of N-WASP by Cdc42
hasComponent
CDC42:GTP:WASP/N-WASP [plasma membrane]
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane]
ITSN1:N-WASP [cytosol]
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane]
Other forms of this molecule
Wasl [endocytic vesicle membrane]
Wasl [plasma membrane]
N-Wasp [cytosol]
phospho-Wasl [cytosol]
Inferred From
N-WASP [cytosol] (Homo sapiens)
WASP/N-WASP [cytosol] (Homo sapiens)
Cross References
PRO
O08816
RGD
735144
PDB
1MKE
,
2IFS
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8X482 ESPFU
0.756
5
UniProt:O08816 Wasl
5
Wasl [plasma membrane]
(R-RNO-203010)
Wasl [endocytic vesicle membrane]
(R-RNO-535012)
Wasl [cytosol]
(R-RNO-201873)
N-Wasp [cytosol]
(R-RNO-442543)
phospho-Wasl [cytosol]
(R-RNO-2197672)
0.73
3
UniProt:P07737 PFN1
2
PFN1 [cytosol]
(R-HSA-203081)
PFN1 [extracellular region]
(R-HSA-350755)
0.639
4
UniProt:P0DJ88 ESFU2
0.618
4
UniProt:P35080 PFN2
1
PFN2 [cytosol]
(R-HSA-3009037)
0.602
3
UniProt:Q60598 Cttn
3
Cttn [cytosol]
(R-MMU-442836)
p-S113-Cttn [cytosol]
(R-MMU-442839)
Cttn [cytosol]
(R-MMU-201894)
0.573
2
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.558
2
UniProt:Q8IVI9 NOSTRIN
2
NOSTRIN [plasma membrane]
(R-HSA-202134)
NOSTRIN [endocytic vesicle membrane]
(R-HSA-535014)
0.524
3
UniProt:P60953 CDC42
3
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [plasma membrane]
(R-HSA-449545)
0.524
2
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