Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PDPK1 [cytosol]
Stable Identifier
R-RNO-202210
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
O55173
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Rattus norvegicus)
Phosphorylation of PDPK1 on serine-241 (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PDPK1 binds PIP2 (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through PI3Kgamma (Rattus norvegicus)
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
PDPK1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O55173 Pdpk1
Gene Names
Pdpk1, Pdk1
Chain
chain:1-559
Reference Genes
BioGPS Gene:81745 Pdpk1
KEGG:rno:81745 Pdpk1
Monarch:81745 Pdpk1
NCBI Gene:81745 Pdpk1
UCSC:O55173 Pdpk1
Reference Transcript
RefSeq:NM_031081.1 Pdpk1
Other Identifiers
10740966
1370052_at
17654277
5697325
5716279
5796066
6102370
6144274
6157614
6165845
6167593
6196715
6212278
6286075
6346236
6401752
6429765
6497706
6518016
6542372
6580199
6713215
6736894
6737108
81745
A_44_P258751
GE1250935
GE18590
GE22243
GO:0002376
GO:0003323
GO:0003824
GO:0004672
GO:0004674
GO:0004676
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0006972
GO:0007173
GO:0008286
GO:0010594
GO:0010667
GO:0012501
GO:0014069
GO:0016004
GO:0016192
GO:0016477
GO:0016740
GO:0019722
GO:0023052
GO:0030154
GO:0030512
GO:0031410
GO:0032869
GO:0034122
GO:0035556
GO:0036211
GO:0042995
GO:0043122
GO:0043226
GO:0043274
GO:0043304
GO:0043536
GO:0045766
GO:0048009
GO:0048856
GO:0048870
GO:0051281
GO:0055065
GO:0055085
GO:0071364
GO:0072659
GO:0097191
GO:0098542
GO:0098772
GO:0140096
GO:1903078
GO:1903672
GO:1905564
GO:2000352
ILMN_1359177
PH_rn_0003053
Y15748_at
Participates
as an input of
Phosphorylation of PDPK1 on serine-241 (Rattus norvegicus)
PIP3 recruits PDK1 and AKT to the membrane (Rattus norvegicus)
PDPK1 binds PIP2 (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
PIP3 recruits PDPK1 to the membrane (Rattus norvegicus)
Other forms of this molecule
phospho-p-S241-PDPK1 [cytosol]
Pdk1 [plasma membrane]
PDPK1 [plasma membrane]
Inferred From
PDPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_112343.1
ENSEMBL
ENSRNOT00000067660
,
ENSRNOP00000061683
,
ENSRNOG00000006136
PRO
O55173
RGD
620307
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text