Reactome | Col1a2 [extracellular region]

Col1a2 [extracellular region]

Stable Identifier

R-RNO-2089976

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL1A2, P02466

Locations in the PathwayBrowser

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Extracellular matrix organization (Rattus norvegicus)

- Collagen formation (Rattus norvegicus)
  - Assembly of collagen fibrils and other multimeric structures (Rattus norvegicus)
    - Crosslinking of collagen fibrils (Rattus norvegicus)
      - Formation of allysine by LOX (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)
        
        Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with dehydro-lysinonorleucine [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-LNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxyallysine by LOX (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HL-Pyr [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HL-Pyrrole [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without L-Pyr [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Formation of lysyl-pyrrole cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without L-Pyrrole [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Formation of collagen fibres (Rattus norvegicus)
      - Collagen fibres [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Collagen fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Formation of collagen fibrils (Rattus norvegicus)
      - Collagen fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Tropocollagens [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)
      - Collagen type I, II fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - Collagen type I,II:XII,XIV fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - Collagen biosynthesis and modifying enzymes (Rattus norvegicus)
    - Removal of fibrillar collagen C-propeptides (Rattus norvegicus)
      - Tropocollagens [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- Degradation of the extracellular matrix (Rattus norvegicus)
  - Collagen degradation (Rattus norvegicus)
    - Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Collagen type I degradation by MMP15 (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- ECM proteoglycans (Rattus norvegicus)
  - BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
      - Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
      - Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)
    - COMP interactors [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - COMP pentamer:COMP interactors [extracellular region] (Rattus norvegicus)
      - COMP interactors [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- FN1 binds Collagen types I-V, VII (Rattus norvegicus)
  - Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
    - Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- Integrin cell surface interactions (Rattus norvegicus)
  - Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- Non-integrin membrane-ECM interactions (Rattus norvegicus)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Rattus norvegicus)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Rattus norvegicus)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)

Hemostasis (Rattus norvegicus)

- Cell surface interactions at the vascular wall (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- Platelet Adhesion to exposed collagen (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - GPIb-IX-V binds to vWF:Collagen complex (Rattus norvegicus)
    - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - vWF binds to collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
- Platelet activation, signaling and aggregation (Rattus norvegicus)
  - GP1b-IX-V activation signalling (Rattus norvegicus)
    - GP1b signaling involves c-Src (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V binds filamin (Rattus norvegicus)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Rattus norvegicus)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - GPVI-mediated activation cascade (Rattus norvegicus)
    - Binding of Syk tyrosine kinase (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - SYK autophosphorylates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
    - p-Y348-SYK dissociates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
  - Platelet Aggregation (Plug Formation) (Rattus norvegicus)
    - Thrombin binding to GP1b:IX:V (Rattus norvegicus)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Rattus norvegicus)
    - OSCAR binds collagen and SP-D (Rattus norvegicus)
      - Collagen types I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen types I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by MET (Rattus norvegicus)
    - MET promotes cell motility (Rattus norvegicus)
      - MET activates PTK2 signaling (Rattus norvegicus)
        
        PTK2 binds activated MET (Rattus norvegicus)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Rattus norvegicus)
        
        Collagen, laminin, fibronectin [extracellular region] (Rattus norvegicus)
        
        Collagen fibres [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a2 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P02466 Col1a2

Gene Names

Col1a2

Chain

signal peptide:1-22, propeptide:23-85, chain:86-1125, propeptide:1126-1372

Reference Genes

BioGPS Gene:84352 Col1a2

KEGG Gene (Rattus norvegicus):84352 Col1a2

Monarch:84352 Col1a2

NCBI Gene:84352 Col1a2

UCSC:P02466 Col1a2

Reference Transcript

RefSeq:NM_053356.1 Col1a2

Participant Of

hasComponent

Tropocollagen type I [extracellular region]

Other forms of this molecule

Col1a2 [endoplasmic reticulum lumen]

Col1a2 [extracellular region]

Collagen alpha-2(I) C-term fragment [extracellular region]

Collagen alpha-2(I) N-term fragment [extracellular region]

Col1a2 [extracellular region]

Collagen alpha-2(I) chain [extracellular region]

Col1a2 [extracellular region]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL1A2 [extracellular region] (Homo sapiens)

Collagen alpha-2(I) chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_445808.1

PRO

P02466

RGD

621351

PDB

3HR2, 3HQV

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