Reactome | Col1a1 [extracellular region]

Col1a1 [extracellular region]

Stable Identifier

R-RNO-2089980

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

3x4Hyp-3Hyp-GalHyl-COL1A1, P02454

Locations in the PathwayBrowser

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Extracellular matrix organization (Rattus norvegicus)

- Collagen formation (Rattus norvegicus)
  - Assembly of collagen fibrils and other multimeric structures (Rattus norvegicus)
    - Crosslinking of collagen fibrils (Rattus norvegicus)
      - Formation of allysine by LOX (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of dehydro-hydroxylysino-norleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of dehydro-lysinonorleucine cross-links (Rattus norvegicus)
        
        Collagen type 1 fibrils cross-linked by dehydro-lysinonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with dehydro-lysinonorleucine [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-LNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without allysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of histidino-hydroxylysinonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with histidino-hydroxylysinoleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxyallysine by LOX (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysino-5-ketonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysyl-pyridinoline cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HL-Pyr [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of hydroxylysyl-pyrrole cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HL-Pyrrole [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of lysino-5-ketonorleucine cross-links (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without hydroxyallysines [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of lysyl-pyridinoline cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with hydroxylysino-5-ketonorleucine crosslinks [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without HLKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysyl-pyridinoline cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without L-Pyr [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Formation of lysyl-pyrrole cross-links (Rattus norvegicus)
        
        Collagen type I fibrils with deH-HLNL cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without deH-HLNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysino-5-ketonorleucine cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without LKNL [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibrils with lysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril with lysyl-pyrrole cross-links [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I with or without L-Pyrrole [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Formation of collagen fibres (Rattus norvegicus)
      - Collagen fibres [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Collagen fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Formation of collagen fibrils (Rattus norvegicus)
      - Collagen fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Tropocollagens [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Type XII and XIV collagens associate with type I and type II fibrils. (Rattus norvegicus)
      - Collagen type I, II fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - Collagen type I,II:XII,XIV fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - Collagen biosynthesis and modifying enzymes (Rattus norvegicus)
    - Removal of fibrillar collagen C-propeptides (Rattus norvegicus)
      - Tropocollagens [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- Degradation of the extracellular matrix (Rattus norvegicus)
  - Collagen degradation (Rattus norvegicus)
    - Collagen type I degradation by MMP1,2,8,13, PRSS2 (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Collagen type I degradation by MMP15 (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- ECM proteoglycans (Rattus norvegicus)
  - BGN binds Collagen types I, VI, (IX) (Rattus norvegicus)
    - BGN:Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
      - Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Collagen types I, VI, (IX) [extracellular region] (Rattus norvegicus)
      - Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - COMP binds collagen, fibronectin, aggrecan and matrilins (Rattus norvegicus)
    - COMP interactors [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - COMP pentamer:COMP interactors [extracellular region] (Rattus norvegicus)
      - COMP interactors [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - DCN binds collagen I, II, III, VI fibrils (Rattus norvegicus)
    - Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - DCN:Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - SPARC binds Collagen type I fibril, hydroxylapatite and Ca2+ (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril:SPARC:Hydroxylapatitie:Ca2+ [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- FN1 binds Collagen types I-V, VII (Rattus norvegicus)
  - Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
    - Collagen types I-V, VII [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- Integrin cell surface interactions (Rattus norvegicus)
  - Collagen type I binds integrin alpha11beta1 (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Collagen type I:Mg2+:Integrin alpha 11 beta 1 [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- Non-integrin membrane-ECM interactions (Rattus norvegicus)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Rattus norvegicus)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Rattus norvegicus)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Rattus norvegicus)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Rattus norvegicus)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)

Hemostasis (Rattus norvegicus)

- Cell surface interactions at the vascular wall (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- Platelet Adhesion to exposed collagen (Rattus norvegicus)
  - Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - GPIb-IX-V binds to vWF:Collagen complex (Rattus norvegicus)
    - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
      - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - vWF binds to collagen (Rattus norvegicus)
    - Collagen type I fibril [extracellular region] (Rattus norvegicus)
      - Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
      - Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
- Platelet activation, signaling and aggregation (Rattus norvegicus)
  - GP1b-IX-V activation signalling (Rattus norvegicus)
    - GP1b signaling involves c-Src (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V binds 14-3-3-zeta (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V binds filamin (Rattus norvegicus)
      - GPIb-IX-V:vWF:filamin-A [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Rattus norvegicus)
        
        GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Rattus norvegicus)
      - GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - GPVI-mediated activation cascade (Rattus norvegicus)
    - Binding of Syk tyrosine kinase (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Rattus norvegicus)
      - GPVI:FceRI gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - SYK autophosphorylates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
    - p-Y348-SYK dissociates (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Rattus norvegicus)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
  - Platelet Aggregation (Plug Formation) (Rattus norvegicus)
    - Thrombin binding to GP1b:IX:V (Rattus norvegicus)
      - GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Rattus norvegicus)
        
        GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Rattus norvegicus)
        
        Collagen type I fibril:vWF [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Rattus norvegicus)
    - OSCAR binds collagen and SP-D (Rattus norvegicus)
      - Collagen types I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)
      - OSCAR:Collagen I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen types I,II,III/SP-D [extracellular region] (Rattus norvegicus)
        
        Collagen type I, II, III, VI fibrils [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by MET (Rattus norvegicus)
    - MET promotes cell motility (Rattus norvegicus)
      - MET activates PTK2 signaling (Rattus norvegicus)
        
        PTK2 binds activated MET (Rattus norvegicus)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Rattus norvegicus)
        
        Collagen, laminin, fibronectin [extracellular region] (Rattus norvegicus)
        
        Collagen fibres [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibre [extracellular region] (Rattus norvegicus)
        
        Collagen type I fibril [extracellular region] (Rattus norvegicus)
        
        Tropocollagen type I [extracellular region] (Rattus norvegicus)
        
        Col1a1 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P02454 Col1a1

Gene Names

Col1a1

Chain

signal peptide:1-22, propeptide:23-151, chain:152-1207, propeptide:1208-1453

Reference Genes

BioGPS Gene:29393 Col1a1

ENSEMBL:ENSRNOG00000003897 Col1a1

KEGG Gene (Rattus norvegicus):29393 Col1a1

Monarch:29393 Col1a1

NCBI Gene:29393 Col1a1

UCSC:P02454 Col1a1

Reference Transcript

RefSeq:NM_053304.1 Col1a1

Other Identifiers

10737532

1370864_at

1388116_at

17650326

29393

5637096

5650889

5654945

5677698

5690588

5703493

5709901

5714661

5753389

5781390

5793943

5801762

5829050

5884651

5890654

5904465

5923661

5929562

5963898

6014611

6015931

6019144

6059876

6067504

6107853

6118147

6122922

6169622

6191220

6202136

6208357

6247463

6329947

6370863

6404744

6423332

6423509

6451670

6452386

6456386

6468296

6469196

6480688

6485472

6492855

6500682

6511985

6583724

6607583

6617386

6671299

6682004

A_44_P238421

A_44_P350521

A_64_P040278

GE21222

GE22042

GO:0001501

GO:0001503

GO:0001568

GO:0001649

GO:0001957

GO:0001958

GO:0002020

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005575

GO:0005576

GO:0005581

GO:0005584

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005794

GO:0006810

GO:0006950

GO:0007155

GO:0007165

GO:0007267

GO:0007584

GO:0007601

GO:0007605

GO:0008150

GO:0009058

GO:0009612

GO:0009790

GO:0010718

GO:0010812

GO:0015031

GO:0019899

GO:0030141

GO:0030154

GO:0030198

GO:0030199

GO:0030335

GO:0031012

GO:0031410

GO:0031667

GO:0031960

GO:0032355

GO:0032964

GO:0032991

GO:0034504

GO:0034505

GO:0034641

GO:0038063

GO:0040011

GO:0042060

GO:0042493

GO:0042542

GO:0042802

GO:0043167

GO:0043226

GO:0043434

GO:0043588

GO:0043589

GO:0044344

GO:0044691

GO:0045893

GO:0046872

GO:0048407

GO:0048545

GO:0048646

GO:0048705

GO:0048706

GO:0048856

GO:0048870

GO:0050877

GO:0051591

GO:0055093

GO:0060325

GO:0060346

GO:0060351

GO:0071230

GO:0071260

GO:0071300

GO:0071306

GO:0071356

GO:0071364

GO:0071560

GO:0090263

GO:1902617

GO:1902618

ILMN_1361396

M27207mRNA_s_at

PH_rn_0002387

PH_rn_0021191

U75405UTR#1_f_at

Z78279_at

Z78279_g_at

rc_AI231472_s_at

Participant Of

hasComponent

Tropocollagen type I [extracellular region]

Other forms of this molecule

Col1a1 [endoplasmic reticulum lumen]

Col1a1 [extracellular region]

Collagen alpha-1(I) chain C-term fragment [extracellular region]

Collagen alpha-1(I) chain N-term fragment [extracellular region]

Col1a1 [extracellular region]

Collagen alpha-1(I) chain [extracellular region]

Col1a1 [extracellular region]

Inferred From

3x4Hyp-3Hyp-GalHyl-COL1A1 [extracellular region] (Homo sapiens)

Collagen alpha-1(I) chains [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

RefSeq

NP_445756.1

Ensembl

ENSRNOG00000003897, ENSRNOT00000005311, ENSRNOP00000005311

PRO

P02454

RGD

61817

PDB

3HQV, 3HR2

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBG0 MRC2	3	MRC2 [clathrin-coated endocytic vesicle membrane] (R-HSA-1236893) MRC2 [plasma membrane] (R-HSA-1216516) MRC2 [early endosome membrane] (R-HSA-1236847)	0.558	2

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