Reactome | DNM1 [cytosol]

DNM1 [cytosol]

Stable Identifier

R-RNO-2213182

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P21575

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        DNM:GDP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        DNM:GTP [cytosol] (Rattus norvegicus)
        
        Dynamin [cytosol] (Rattus norvegicus)
        
        DNM1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P21575 Dnm1

Gene Names

Dnm1, Dnm

Chain

chain:1-864

Reference Genes

BioGPS Gene:140694 Dnm1

dbSNP Gene:140694 Dnm1

ENSEMBL:ENSRNOG00000033835 Dnm1

KEGG Gene (Rattus norvegicus):140694 Dnm1

Monarch:140694 Dnm1

NCBI Gene:140694 Dnm1

UCSC:P21575 Dnm1

Reference Transcript

RefSeq:NM_080689.4 Dnm1

Other Identifiers

10844302

1368292_at

140694

17771257

2AKA

3ZVR

5663636

5682696

5712111

5712949

5731799

5799783

5832832

5852446

5912055

5913411

5951251

5967542

6060168

6074777

6100656

6188625

6517671

6573999

6576409

6581845

6596632

6614947

6683224

71096

A_44_P468182

A_64_P144223

CAA38397

CB583951

CB708564

CO398357

Dnm1

Dnm1-201

Dnm1-202

ENSRNOG00000033835

ENSRNOP00000041582

ENSRNOP00000060845

ENSRNOT00000047921

ENSRNOT00000064039

EntrezGene:140694

EntrezGene:Dnm1

GE21106

GO:0000166

GO:0001917

GO:0002031

GO:0003674

GO:0003924

GO:0005515

GO:0005525

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005856

GO:0005874

GO:0005886

GO:0006810

GO:0006897

GO:0006898

GO:0007032

GO:0007165

GO:0007267

GO:0008017

GO:0008021

GO:0008022

GO:0008092

GO:0008150

GO:0014069

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0017124

GO:0019899

GO:0019901

GO:0030117

GO:0030424

GO:0031410

GO:0031623

GO:0031749

GO:0032991

GO:0042802

GO:0043167

GO:0043196

GO:0043197

GO:0043226

GO:0044327

GO:0044877

GO:0045202

GO:0045211

GO:0048488

GO:0050803

GO:0050804

GO:0050998

GO:0061024

GO:0072583

GO:0098684

GO:0098835

GO:0098844

GO:0098884

GO:0098978

GO:1900242

GO:1900244

GO:1901998

GO:1903423

GO:1904645

ILMN_1359581

IPR000375

IPR001401

IPR001849

IPR003130

IPR011993

IPR019762

IPR020850

IPR022812

IPR027417

IPR027741

IPR030381

NM_080689

NP_542420

PF00169

PF00350

PF01031

PF02212

PH_rn_0012162

PR00195

SM00053

SM00233

SM00302

UPI0000129A1F

UPI0001750254

X54531

X54531mRNA_at

Participant Of

hasCandidate

Dynamin [cytosol]

Other forms of this molecule

DNM1 [lysosomal membrane]

Dynamin 1 [plasma membrane]

DNM1 [plasma membrane]

Inferred From

DNM1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_542420.1

IntEnz

3.6.5.5

ZINC target

P21575

PRO

P21575

ZINC - Predictions - Purchasable

DYN1_RAT

PDB

3ZVR, 2AKA

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O35179 Sh3gl2	5	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) SH3GL2 [Golgi membrane] (R-RNO-351189) Endophilin [plasma membrane] (R-RNO-182026) SH3GL2 [plasma membrane] (R-RNO-177495) SH3GL2 [cytosol] (R-RNO-182958)	0.785	7
UniProt:P62994 Grb2	3	GRB2-1 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) GRB2-1 [cytosol] (R-RNO-74686)	0.524	3