Phosphorylation of PLC-gamma

Stable Identifier
R-RNO-2730881
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of PLC-gamma
Tyrosine phosphorylation of PLC-gamma enhances its catalytic activity. BTK and SYK are involved in the phosphorylation of PLC-gamma (PLCG). Phosphorylation of tyrosine residues 753, 759, 1197, and 1217 in PLCG2 and 771, 783, and 1254 in PLCG1 have been identified as BTK/SYK-dependent phosphorylation sites.
Literature References
PubMed ID Title Journal Year
15184383 Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker

Rawlings, DJ, Griffith, N, Kipp, K, Dangelmaier, C, Daniel, JL, Turk, CW, Humphries, LA, Sommer, K, Bakman, I, Kato, RM

J. Biol. Chem. 2004
11507089 Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling

Matsushita, M, Tsukada, S, Kishimoto, T, Ishiai, M, Hashimoto, S, Watanabe, D, Kurosaki, T, Baba, Y

J. Biol. Chem. 2001
20807769 Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Hicks, SN, Sondek, J, Harden, TK, Gresset, A

J. Biol. Chem. 2010
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Btk [cytosol]

Physical Entity
Btk [cytosol] (Rattus norvegicus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylated BTK phosphorylates PLCG2 (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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