Notch2 binds Cntn1

Stable Identifier
R-RNO-2974714
Type
Reaction
Species
Rattus norvegicus
Compartment
Summation

Endogenous Notch2 and Cntn1 (F3 i.e. contactin-1) can be co-immunoprecipitated from rat brain lysate. Also, co-culture of rat oligodendrocyte cell line OLN-93 with Chinese hamster ovary (CHO) cells expressing exogenous mouse Cntn1 results in production of the intracellular domain of Notch2, NICD2, indicating that Cntn1 activates Notch2 (Hu et al. 2003).

Literature References
PubMed ID Title Journal Year
14567914 F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

Hu, QD, Ang, BT, Karsak, M, Hu, WP, Cui, XY, Duka, T, Takeda, Y, Chia, W, Sankar, N, Ng, YK, Ling, EA, Maciag, T, Small, D, Trifonova, R, Kopan, R, Okano, H, Nakafuku, M, Chiba, S, Hirai, H, Aster, JC, Schachner, M, Pallen, CJ, Watanabe, K, Xiao, ZC

Cell 2003
Participants
Orthologous Events
Authored
Reviewed