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Crk [cytosol]
Stable Identifier
R-RNO-2980677
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CRK, Q63768
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL binds CRK (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
CBL:CRKL binds RAPGEF1 (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK:RAPGEF1 [cytosol] (Rattus norvegicus)
p(Y700,731,774)-CBL:CRK [cytosol] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Rattus norvegicus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
Crk binding to p130cas (Rattus norvegicus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signaling by Non-Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PTK6 (Rattus norvegicus)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Rattus norvegicus)
Activation of RAC1 by the PXN:CRK complex (Rattus norvegicus)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates RAP1 and RAC1 (Rattus norvegicus)
CRK,CRKL recruits RAC1 GEF to activated MET (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
DOCK7 activates RAC1 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
GAB1 recruits CRK,CRKL to MET (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
RAPGEF1 activates RAP1 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
RAPGEF1 binds CRK,CRKL (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
MET receptor recycling (Rattus norvegicus)
GGA3 associates with activated MET receptor (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
ARMS-mediated activation (Rattus norvegicus)
ARMS is phosphorylated by active TrkA receptor (Rattus norvegicus)
Active TrkA receptor:ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
ARMS:Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Phospho-ARMS:Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
C3G stimulates nucleotide exchange on Rap1 (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Phospho-ARMS:Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Crk's SH3 domain engages C3G (Rattus norvegicus)
Active TrkA receptor:Phospho-ARMS:Crk complex [plasma membrane] (Rattus norvegicus)
Phospho-ARMS:Crk [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
Crk binds to the active PDGF receptor (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
p130Cas and C3G bind PDGFR bound Crk (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk:p130Cas:C3G [plasma membrane] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:Crk [plasma membrane] (Rattus norvegicus)
CRK, CRKL [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
CRK binds BCAR1 and or PXN (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Rattus norvegicus)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Rattus norvegicus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
Crk [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q63768 Crk
Gene Names
Crk, Crko
Chain
initiator methionine:, chain:2-304
Reference Genes
BioGPS Gene:54245 Crk
KEGG:rno:54245 Crk
Monarch:54245 Crk
NCBI Gene:54245 Crk
UCSC:Q63768 Crk
Reference Transcript
RefSeq:NM_019302.1 Crk
Other Identifiers
10736033
1369912_at
17648676
54245
6121614
6481129
6542610
6548053
6671397
6682284
A_44_P275249
D44481_at
GE20648
GE21604
GO:0001764
GO:0001784
GO:0002376
GO:0002685
GO:0005515
GO:0005856
GO:0006629
GO:0007010
GO:0007155
GO:0007163
GO:0007167
GO:0008283
GO:0008360
GO:0009966
GO:0015629
GO:0016020
GO:0016358
GO:0017124
GO:0019900
GO:0021766
GO:0021987
GO:0023052
GO:0030010
GO:0030036
GO:0030154
GO:0030159
GO:0031594
GO:0031625
GO:0032956
GO:0032991
GO:0033628
GO:0034330
GO:0035022
GO:0035591
GO:0035685
GO:0038026
GO:0042060
GO:0042169
GO:0043226
GO:0043621
GO:0045309
GO:0046875
GO:0048013
GO:0048856
GO:0048870
GO:0050773
GO:0060090
GO:0060326
GO:0061024
GO:0061045
GO:0098698
GO:0098749
GO:1900026
GO:1902531
GO:1904395
GO:1990782
GO:2000146
GO:2000404
ILMN_1361978
PH_rn_0011435
Participates
as an input of
Crk binding to p130cas (Rattus norvegicus)
CRK binds BCAR1 and or PXN (Rattus norvegicus)
as a component of
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Rattus norvegicus)
Phospho-ARMS:Crk [cytosol] (Rattus norvegicus)
ARMS:Crk [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Rattus norvegicus)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Rattus norvegicus)
as a member of
CRK, CRKL [cytosol] (Rattus norvegicus)
Other forms of this molecule
Crk [cytosol]
Inferred From
CRK [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_062175.1
ENSEMBL
ENSRNOG00000025792
,
ENSRNOT00000006407
,
ENSRNOP00000006407
PRO
Q63768
RGD
2405
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
2
PTPN1 [endosome membrane]
(R-HSA-9815895)
PTPN1 [cytosol]
(R-HSA-210625)
0.589
2
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